The Buffalo Bills will host the Kansas City Chiefs on Sunday in a pivotal AFC matchup at Highmark Stadium, with kickoff scheduled for 4:25 p.m. ET.

Throughout the week, uncertainty around key starters has dominated conversations in Orchard Park, as wide receiver Joshua Palmer (ankle) and defensive tackle DaQuan Jones (calf) were both held out of Wednesday’s practice. Running back Ray Davis also missed the session due to illness.

Meanwhile, the Bills received encouraging news at linebacker. Terrel Bernard (ankle) and Matt Milano (pectoral) were full participants on Wednesday after being limited all last week, signaling progress for Buffalo’s defense ahead of facing Patrick Mahomes and the Chiefs.

Head coach Sean McDermott said the team will monitor how the returning players respond to practice before finalizing Sunday’s lineup.

“Yeah, we have to evaluate,” McDermott said. “We got to take it one day at a time just because of some of the different things that we’ve had going on health-wise. So we wanna look at practice and then go from there.”

These updates prompted Dimers’ analysts to reevaluate their Bills vs. Chiefs predictions and player stat projections using new simulations that factored in the latest injury developments on both sides of the ball.

The results of Dimers’ simulations were compared to updated sportsbook odds to compile the data-driven Bills-Chiefs preview below.

Chiefs vs. Bills betting preview

Explore the interactive widget below to see the current spread, total, and moneyline betting odds and probabilities for the Chiefs-Bills game at Highmark Stadium.

This prediction and best bet for Sunday’s NFL matchup between the Chiefs and Bills is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Chiefs vs. Bills NFL game.

Teams: Kansas City Chiefs vs. Buffalo BillsDate: Sunday, November 2, 2025Kickoff: 4:25 p.m. ESTLocation: Highmark StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL battle between the Chiefs and Bills.

Spread: Chiefs -1.5 (-114), Bills +1.5 (-105)Moneyline: Chiefs -130, Bills +115Total: Over/Under 52.5 (-105/-112)

The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

Expert prediction: Chiefs vs. Bills

Leveraging trusted data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Sunday’s Chiefs vs. Bills matchup.

According to Dimers’ renowned predictive analytics model, the Chiefs are more likely to defeat the Bills at Highmark Stadium. This prediction is based on the model giving the Chiefs a 57% chance of winning the game.

Elsewhere on the betting board, Dimers predicts that the bookies have gotten it right and the Chiefs and Bills each have a 50% chance of covering the spread, while the 52.5-point over/under has a 54% chance of staying under.

These predictions and probabilities are correct at the time of publication but are subject to potential changes.

Chiefs vs. Bills best bet

Our top pick for the Chiefs vs. Bills Week 9 NFL matchup is to bet on Under 52.5 points (-112).

This betting advice is based on cutting-edge modeling and valuable wagering intelligence, designed to bring you the best possible plays.

Score prediction for Chiefs vs. Bills

Dimers’ predicted final score for the Kansas City vs. Buffalo game on Sunday has the Chiefs prevailing 26-24.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

Kansas City Chiefs stat projectionsFirst touchdown scorer predictionsRashee Rice: 9.5% probabilityKareem Hunt: 8.4% probabilityTravis Kelce: 6.9% probabilityAnytime touchdown predictionsRashee Rice: 48.3% probabilityKareem Hunt: 44.0% probabilityTravis Kelce: 38.1% probabilityProjected box score leadersQB passing yards: Patrick Mahomes, 273 yardsReceiving yards: Rashee Rice, 74 yardsRushing yards: Kareem Hunt, 39 yardsBuffalo Bills stat projectionsFirst touchdown scorer predictionsJames Cook: 10.7% probabilityJosh Allen: 6.7% probabilityKhalil Shakir: 5.4% probabilityAnytime touchdown predictionsJames Cook: 53.8% probabilityJosh Allen: 38.3% probabilityKhalil Shakir: 32.1% probabilityProjected box score leadersQB passing yards: Josh Allen, 243 yardsReceiving yards: Khalil Shakir, 55 yardsRushing yards: James Cook, 79 yardsNFL Week 9: Chiefs vs. Bills

Get ready for Sunday’s matchup between the Chiefs and Bills in Week 9 of the National Football League season at Highmark Stadium, which is scheduled to start at 4:25 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions on this page are derived from 10,000 data-driven simulations of the Chiefs vs. Bills matchup, and they are correct at the time of publication. They aim to help you make better decisions when placing bets at online sportsbooks.

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