The Kansas City Chiefs (5-3) are favored by 1.5 points as they fight to keep their three-game winning streak going in a matchup with the Buffalo Bills (5-2) on Sunday, November 2, 2025 at Highmark Stadium.

Chiefs vs. Bills game infoGame day: Sunday, November 2, 2025Game time: 4:25 p.m. ETTV channel: CBSLocation: Orchard Park, New YorkStadium: Highmark StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

Watch Kansas City Chiefs vs. Buffalo Bills on Fubo! (Regional restrictions may apply)

Chiefs vs. Bills odds & betting linesSpread favorite: Kansas City (-1.5)Moneyline: Kansas City (-133), Buffalo (+112)Total: 52.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Chiefs vs. Bills recent matchupsThe last five matchups between these two teams have resulted in a Dallas victory three times.The Bills are 3-2 against the spread in those games against the Chiefs, while the two teams have gone over the point total on three occasions.Buffalo has had the scoring advantage in those five matchups, recording 127 points while Kansas City put up 117.Chiefs vs. Bills betting insightsKansas City is 5-3-0 against the spread so far this season. In six games as a moneyline favorite, the Chiefs are 4-2. Buffalo has a 3-4-0 record against the spread so far this season. The Bills have played as the underdog on the moneyline once so far this season and won.Chiefs scoring insightsThe Chiefs are averaging more points at home (28.6) than on the road (23.7).On defense, Kansas City allows fewer points at home (12.8 per game) than on the road (22.3).The Chiefs have been surging on both sides of the ball over the last three contests, ranking fifth-best on offense (29.7 points per game) and best on defense (8.0 points allowed per game).Bills scoring insightsAt home, the Bills score 30.8 points per game, higher than their 28.0 average on the road.Defensively, Buffalo is conceding 25.8 points per game at home, more than its 14.3 average away from home.On offense, the Bills average fewer points in division games (27.0) than outside the division (31.5).Buffalo averages fewer points allowed in division games (18.0) than outside the division (23.0).In their past three games, the Bills are putting up 24.7 points per game (16th in NFL), and conceding 18.7 (sixth).Chiefs injury reportChiefs:
Nick Bolton: Full Participation in Practice (Knee),
Trey Smith: Limited Participation in Practice (Back),
Marquise Brown: Full Participation in Practice (Illness),
Isiah Pacheco: Did Not Participate In Practice (Knee),
Josh Simmons: Did Not Participate In Practice (NIR – Personal),
Jawaan Taylor: Full Participation in Practice (Knee),
Brashard Smith: Full Participation in Practice (Toe),
Charles Omenihu: Full Participation in Practice (Ankle),
Kareem Hunt: Full Participation in Practice (Ankle)Bills injury reportBills:
Shaq Thompson: Did Not Participate In Practice (Hamstring),
Matt Prater: Limited Participation in Practice (Calf),
Jordan Phillips: Full Participation in Practice (Rest),
Josh Palmer: Limited Participation in Practice (Knee),
Matt Milano: Full Participation in Practice (Pectoral),
DaQuan Jones: Did Not Participate In Practice (Calf),
Ray Davis: Full Participation in Practice (Illness),
Joey Bosa: Full Participation in Practice (Rest),
Terrel Bernard: Full Participation in Practice (Ankle)

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