On Sunday, November 2, 2025, the San Francisco 49ers (5-3) are favored by just 2.5 points against the New York Giants (2-6). The game’s total has been listed at 48.5 points.
Looking to place a parlay bet on this game? See insights, including first to score and player prop bet insights, in this article.
49ers vs. Giants game odds
NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 7:41 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread: 49ers -2.5 (-120 to cover)Moneylines: 49ers -155, Giants +130Total: 48.5 points (Over: -110, Under: -110)Pick ATS: 49ers (-2.5)Pick OU: Under (48.5)Prediction:
49ers 24 – Giants 20First TD odds and insights
First TD odds: 49ers -135, Giants +100
The 49ers have scored the first TD in five games out of the eight they’ve played so far.In those five games, four of San Francisco’s scores came via the pass, and one rushing.In the first quarter, the 49ers are 15th in the league in terms of TDs scored (three).The Giants have scored the opening TD in six games out of the eight they’ve played thus far.In those six games, three of New York’s scores came rushing the ball, and three in the air.Looking at only first quarters, the Giants have scored six touchdowns, the fifth-most of all teams this year.
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Christian McCaffrey player propsRushing yard prop: Over/under 77.5 yardsReceiving yard prop: Over/under 46.5 yardsChristian McCaffrey’s rushing yards over/under is set at 77.5 yards, compared to his season average of 61.3 yards per game.Mac Jones player propsPassing yard prop: Over/under 243.5 yardsRushing yard prop: Over/under 8.5 yardsSunday’s passing yards over/under for Mac Jones is set at 243.5, 22.7 yards fewer than his season average of 266.2.Jaxson Dart player propsPassing yard prop: Over/under 210.5 yardsRushing yard prop: Over/under 37.5 yardsJaxson Dart averages 140.6 passing yards per game this season, which is less than his prop bet total for this matchup of 210.5.Wan’Dale Robinson player propsReceiving yard prop: Over/under 51.5 yardsWan’Dale Robinson’s 61.8 receiving yards per game are 10.3 more than his prop bet over/under for Sunday’s game (51.5).