The Kansas City Chiefs‘ (5-3) injury report has 10 players on it ahead of their Sunday, Nov. 2 matchup versus the Buffalo Bills (5-2) at Highmark Stadium. It begins at 4:25 p.m. ET.
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Chiefs vs Bills TV channel & game infoGame day: Sunday, November 2, 2025Game time: 4:25 p.m. ETLocation: Orchard Park, New YorkStadium: Highmark StadiumTV channel: CBSLive stream: Watch on Fubo! (Regional restrictions may apply)Live stream: Watch on Paramount+! (Regional restrictions may apply)
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Chiefs injury reportIsiah Pacheco | RB (Out)Injury: KneePractice Status: Did Not Participate In Practice2025 Rushing: 78 Attempts | 329 Yards | 1 TouchdownJosh Simmons | OT (Out)Injury: NIR – PersonalPractice Status: Did Not Participate In Practice2025 Season Stats: 3 Games PlayedTrey Smith | OG (Questionable)Injury: BackPractice Status: Full Participation in Practice2024 Season Stats: 8 Games PlayedJaylon Moore | OL (Questionable)Injury: IllnessPractice Status: Did Not Participate In PracticeNick Bolton | LBInjury: KneePractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 4.0 Tackles for Loss | 61 Tackles | 0 Interceptions | 2 Passes DefendedMarquise Brown | WRInjury: IllnessPractice Status: Full Participation in Practice2025 Receiving Stats: 49 Targets | 32 Receptions | 316 Yards | 4 TouchdownsJawaan Taylor | OTInjury: KneePractice Status: Full Participation in Practice2025 Season Stats: 4 Games PlayedBrashard Smith | RBInjury: ToePractice Status: Full Participation in PracticeCharles Omenihu | DEInjury: AnklePractice Status: Full Participation in PracticeKareem Hunt | RBInjury: AnklePractice Status: Full Participation in Practice2025 Rushing: 62 Attempts | 245 Yards | 4 TouchdownsChiefs insightsThe Chiefs have put up more points per game over their previous three matchups (29.7) than they have averaged for the season (26.8).Turning our focus to yardage, Kansas City has racked up more total yards per game over its past three matchups (407) than it has averaged for the season (378.3).In the passing game, the Chiefs are amassing 251.8 passing yards per game this season, but they’ve been more effective over their last three games, averaging 269.7 passing yards per contest.Kansas City has tallied more rushing yards per game over its last three matchups (137.3) than it has averaged for the season (126.5).Chiefs vs Bills odds
NFL odds courtesy of BetMGM. Odds updated Sunday at 1:24 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Chiefs (-1.5)Moneyline: Chiefs (-131), Bills (+110)Total: 52.5 points
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