The Arizona Cardinals (3-5) visit the Seattle Seahawks (6-2) at Lumen Field in Seattle for a Week 10 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, November 9, including live updated odds and injury report news.

NameWeek 92025 SeasonJon Hoefling7-769-63-3Tyler Dragon6-868-64-3Blake Schuster10-465-54-3Lorenzo Reyes6-863-71-3Chris Bumbaca5-959-73-3Jordan Mendoza7-753-50-2Richard MorinN/A25-12-1Seahawks vs. Cardinals live odds, moneyline, over/under

Opening Lines

Spread: Seattle Seahawks (-1.5)Moneyline: Seattle Seahawks (-122), Arizona Cardinals (+102)Over/Under: 45.5

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Seahawks vs. Cardinals picks against the spreadTyler Dragon: Seattle Seahawks (-6.5)

Jacoby Brissett’s earned the starting QB spot in Arizona, but it won’t matter who QB1 is in this one. The Seahawks are one of the hottest teams in football. Jaxon Smith-Njigba is an Offensive Player of the Year candidate.

Jon Hoefling: Arizona Cardinals (+6.5)

The Arizona Cardinals have been balling out ATS as of late, going 3-0 since their loss to the Titans. While the possible return of Kyler Murray could throw everything out of whack, I’ll assume it will actually enhance the Cardinals.

Jordan Mendoza: Seattle Seahawks (-6.5)

Seattle may have had the best week with its resounding win against the Commanders. Now back at home, the Seahawks feast again, regardless of who is under center for the Cardinals.

Blake Schuster: Seattle Seahawks (-6.5)

The Cardinals quarterback saga is tough to parse. Even still, the Seahawks have swept this series each of the last three seasons. Arizona has only won at Seattle once since 2020.

Lorenzo Reyes: Seattle Seahawks (-6.5)

It’s alarming that Arizona’s offense looks better with Jacoby Brissett at quarterback, but he’ll start at least one more game. Either way, the Seahawks at home, with their defense playing the way it is and the Sam Darnold-Jaxon Smith-Njigba connection being as solid as it is, I really like the Seahawks here.

Christopher Bumbaca: Seattle Seahawks (-6.5)

I want to think the Cardinals can keep it close but the Seahawks might just be that good. Rashid Shaheed doesn’t need to learn a whole playbook to run under a Sam Darnold pass down the field.

Seahawks vs. Cardinals updated injury reportNFL Week 10 picks, predictions odds

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