The Los Angeles Rams (6-2) are favored by 4.5 points as they try to keep their three-game winning streak alive in a matchup with the San Francisco 49ers (6-3) on Sunday, November 9, 2025 at Levi’s Stadium.

Rams vs. 49ers game infoGame day: Sunday, November 9, 2025Game time: 4:25 p.m. ETTV channel: FOXLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)

Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)

Rams vs. 49ers odds & betting linesSpread favorite: Los Angeles (-4.5)Moneyline: Los Angeles (-224), San Francisco (+183)Total: 49.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Rams vs. 49ers recent matchupsIn the last five meetings between the Rams and 49ers, Los Angeles has gone 3-2.The Rams have a 4-1 record against the spread in those games versus the 49ers, and the two team outpaced the total on four occasions.Los Angeles and San Francisco each totaled 106 points in those five games.Rams vs. 49ers betting insightsLos Angeles is 6-2-0 against the spread this season. The Rams have been named the moneyline favorite seven times this season, and they have recorded a 6-1 record in those outings. San Francisco has five wins against the spread so far this season (5-4-0). This is the fourth time this year the 49ers are the moneyline underdog. They are 1-2 in games as the underdog.Rams scoring insightsThe Rams’ scoring average at home, 24.5 points per game, is worse than their average away, 27.8.On defense, Los Angeles allows more points at home (16.3 per game) than away (15.5), but not by much.While the Rams rank seventh in points per game over the last three games (28.7), they rank best on defense (6.7 points allowed per game) during that three-game period.49ers scoring insightsAt home, the 49ers score 19.0 points per game, which is worse than their 22.8 average on the road.On defense, San Francisco is giving up 17.0 points per game at home, less than its 22.8 average on the road.Offensively, the 49ers average fewer points in division games (19.7) than outside the division (22.5).San Francisco is giving up 17.0 points per game in divisional contests, which is better than its 22.8 average in non-division games.In terms of points scored, including the past three games only, the 49ers are 17th in the NFL (23.0 per game). On the other side of the ball they are ninth in points conceded (20.0).Rams injury reportRams:
Puka Nacua: Full Participation in Practice (Chest),
Jordan Whittington: Did Not Participate In Practice (Back),
Darious Williams: Full Participation in Practice (Shoulder)49ers injury report49ers:
Jake Brendel: Limited Participation in Practice (Hamstring),
Tatum Bethune: Limited Participation in Practice (Thigh),
Trent Williams: Full Participation in Practice (Rest),
Keion White: Limited Participation in Practice (Groin),
Mykel Williams: Did Not Participate In Practice (Knee),
Ricky Pearsall: Did Not Participate In Practice (Knee),
Christian McCaffrey: Full Participation in Practice (Rest),
Kalia Davis: Limited Participation in Practice (Ankle),
Alfred Collins: Did Not Participate In Practice (Hip),
Darrell Luter: Full Participation in Practice (Achilles),
Mac Jones: Full Participation in Practice (Knee),
Jauan Jennings: Full Participation in Practice (Ankle),
Ben Bartch: Full Participation in Practice (Ankle),
Dee Winters: Did Not Participate In Practice (Knee),
Brock Purdy: Limited Participation in Practice (Toe),
Bryce Huff: Limited Participation in Practice (Hamstring)

Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)