Rams vs. 49ers prediction, pick, odds for Sunday's NFL Week 10 game

Rams vs. 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 9:19 p.m.

Moneyline (ML): Los Angeles -220 (Bet $220 to win $100) | San Francisco +180 (Bet $100 to win $180)Against the spread (ATS): Los Angeles -4.5 (-110) | San Francisco +4.5 (-110)Over/Under (O/U): 49.5 (O: -110 | U: -110)Rams vs. 49ers betting tips preview

Check out best bets as the Los Angeles Rams (6-2) will aim to extend a three-game winning streak when they visit the San Francisco 49ers (6-3) on Sunday, November 9, 2025 at Levi’s Stadium.

The Rams picked up the win over the New Orleans Saints, 34-10, in their most recent outing. The 49ers picked up a 34-24 victory last time out against the Giants. Last time out for the Rams, Matthew Stafford finished with 24 completions on 32 attempts (75.0%) for 281 yards, tossing four touchdowns. Kyren Williams carried the ball 25 times for 114 yards and one touchdown. Puka Nacua caught seven passes for 95 yards with one touchdown.

In the 49ers’ last game, Mac Jones threw for 235 yards on 19-24 passing (79.2%), throwing two touchdowns. Christian McCaffrey rushed for one touchdown while racking up 106 yards on 28 attempts. He also hauled in five receptions for 67 yards and one touchdown. Jauan Jennings gained 41 yards on four receptions with one score.

Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)

Rams vs. 49ers key injuriesRamsWR Puka Nacua (chest) full participation in practiceWR Jordan Whittington (back) did not participate in practiceCB Darious Williams (shoulder) full participation in practice49ersOL Ben Bartch (ankle) full participation in practiceLB Tatum Bethune (thigh) limited participation in practiceOL Jake Brendel (hamstring) limited participation in practiceDT Alfred Collins (hip) did not participate in practiceDL Kalia Davis (ankle) limited participation in practiceDL Bryce Huff (hamstring) limited participation in practiceWR Jauan Jennings (ankle) full participation in practiceQB Mac Jones (knee) full participation in practiceCB Darrell Luter (achilles) full participation in practiceRB Christian McCaffrey (rest) full participation in practiceWR Ricky Pearsall (knee) did not participate in practiceQB Brock Purdy (toe) limited participation in practiceDL Keion White (groin) limited participation in practiceOT Trent Williams (rest) full participation in practiceDL Mykel Williams (knee) did not participate in practiceLB Dee Winters (knee) did not participate in practiceRams vs. 49ers prediction

Rams 24, 49ers 19

Moneyline pick: Rams -220The Rams have an implied moneyline win probability of 68.8% in this matchup.Los Angeles has gone 6-1 in games they were favored on the moneyline (winning 85.7% of those games).The Rams have a 3-1 record (winning 75% of their games) when playing as a moneyline favorite of -220 or shorter.San Francisco has won one of the three games it has played as an underdog this season.The 49ers have played as an underdog of +180 or more once this season and won that game.Pick ATS: Rams (-4.5)Los Angeles is 6-2-0 ATS this season.This season, the Rams have an ATS record of 3-1 in their four games as a favorite of 4.5 points or more.In San Francisco’s nine games this year, it has five wins against the spread.The 49ers have been underdogs by 4.5 points or more once this year and covered the spread.Pick OU: Under (49.5)In two games this season, the Rams and their opponents have combined to put up more than 49.5 points.The 49ers have combined with their opponent to score more than 49.5 points just once this season.The teams average 47.7 points per game combined, 1.8 fewer than this matchup’s over/under.These teams together surrender 36.8 points per game, 12.7 fewer than this matchup’s over/under.

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Rams vs. 49ers prediction, pick, odds for Sunday’s NFL Week 10 game

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