A pair of star pass-catchers will be featured when Puka Nacua and the Los Angeles Rams (6-2) visit Christian McCaffrey and the San Francisco 49ers (6-3) on Sunday, November 9, 2025.
With 352.1 total yards per game on the offensive side of the ball, the 49ers rank 10th in the NFL in 2025. On defense, they rank 18th, giving up 332.6 total yards per contest. Offensively, the Rams rank seventh in the NFL with 369.9 yards per game. Meanwhile, they rank 10th in total defense (302.9 yards allowed per contest).
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
49ers vs Rams: Live streaming info, TV channel & game timeGame day: Sunday, November 9, 2025Game time: 4:25 p.m. ETLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
49ers vs Rams betting lines
NFL odds courtesy of BetMGM. Odds updated Saturday at 4:29 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Rams (-5.5)Moneyline: Rams (-253), 49ers (+204)Total: 49.5 points
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)