Los Angeles (6-2) rides a three-game winning streak into a matchup with San Francisco (6-3) on Sunday, November 9, 2025 at Levi’s Stadium. The Rams are listed as favorites in this one, with the spread sitting at 5.5 points. The over/under is 49.5 in the contest.
Last time out, the 49ers defeated the New York Giants, with 34-24 being the final score.
Niners quarterback Mac Jones went 19-for-24 for 235 yards, with two TDs and no INTs, against the Giants.
The Rams’ most recent game was versus the New Orleans Saints, and they won by a score of 34-10.
49ers vs Rams betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 4:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Los Angeles (-5.5)Moneyline: Los Angeles (-256), San Francisco (+207)Total: 49.5 points49ers betting insightsSan Francisco has one win against the spread, and is 2-1 overall, at home this season.The 49ers have covered the spread in a matchup five times this season (5-4-0).The 49ers are a perfect 1-0 ATS when playing as at least 5.5-point underdogs.This season, in three home games, San Francisco has gone over the total once.49ers games have gone over the total five times this year.49ers leadersJones: 1,832 PASS YDS / 261.7 YPG / 67.2% / 10 TD / 5 INTChristian McCaffrey: 168 CAR / 596 YDS / 66.2 YPG / 4 TD / 61 REC / 626 YDS / 69.6 YPG / 4 TDBrian Robinson Jr.: 41 CAR / 197 YDS / 21.9 YPG / 1 TD / 5 REC / 11 YDS / 1.2 YPG / 0 TDKendrick Bourne: 30 REC / 463 YDS / 57.9 YPG / 0 TDRicky Pearsall: 20 REC / 327 YDS / 81.8 YPG / 0 TD49ers vs Rams game infoDate: Sunday, November 9, 2025Time: 4:25 p.m. ETCity: Santa Clara, CaliforniaVenue: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)