Los Angeles (6-2) rides a three-game winning streak into a matchup with San Francisco (6-3) on Sunday, November 9, 2025 at Levi’s Stadium. The Rams are listed as favorites in this one, with the spread sitting at 5.5 points. The over/under is set at 49.5 in the outing.
The Rams beat the New Orleans Saints, 34-10, in their most recent contest.
The Rams’ Matthew Stafford was 24-for-32 for 281 yards versus the Saints, with four TDs and no INTs.
The 49ers’ most recent game was versus the New York Giants, and they won by a score of 34-24.
Rams vs 49ers betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:35 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Los Angeles (-5.5)Moneyline: Los Angeles (-255), San Francisco (+206)Total: 49.5 pointsRams betting insightsLos Angeles is 3-1 overall, and 3-1 against the spread, in away games.The Rams have covered the spread in a matchup six times this season (6-2-0).Away from home, Los Angeles is unbeaten ATS (2-0) as 5.5-point favorites or more.In games they have played as 5.5-point favorites or more, the Rams have an ATS record of 3-1.In four road games this season, Los Angeles has hit the over twice.This season, Rams games have hit the over three times.Rams leadersStafford: 2,147 PASS YDS / 268.4 YPG / 67.2% / 21 TD / 2 INTKyren Williams: 132 CAR / 586 YDS / 73.3 YPG / 3 TD / 20 REC / 166 YDS / 20.8 YPG / 3 TDBlake Corum: 54 CAR / 251 YDS / 31.4 YPG / 1 TD / 4 REC / 15 YDS / 1.9 YPG / 0 TDPuka Nacua: 61 REC / 711 YDS / 101.6 YPG / 3 TDDavante Adams: 36 REC / 491 YDS / 61.4 YPG / 8 TDRams vs 49ers game infoDate: Sunday, November 9, 2025Time: 4:25 p.m. ETCity: Santa Clara, CaliforniaVenue: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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