A pair of excellent pass-catchers will be featured when Puka Nacua and the Los Angeles Rams (6-2) visit Christian McCaffrey and the San Francisco 49ers (6-3) on Sunday, November 9, 2025.
The Rams are putting up 369.9 yards per game on offense, which ranks them seventh in the NFL. On the defensive side of the ball, they rank 10th, surrendering 302.9 yards per contest. With 21.6 points per game on offense, the 49ers rank 23rd in the NFL. Defensively, they rank ninth, allowing 20.9 points per game.
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Rams vs 49ers: live streaming info, TV channel & game timeGame day: Sunday, November 9, 2025Game time: 4:25 p.m. ETLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)
Rams vs 49ers betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:28 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Rams (-5.5)Moneyline: Rams (-255), 49ers (+206)Total: 49.5 points
Watch Los Angeles Rams vs. San Francisco 49ers on Fubo! (Regional restrictions may apply)