The Buffalo Bills’ 2025 opponents have been known for months.
A few heavyweights are on this year’s slate, including clashes with the Kansas City Chiefs, defending Super Bowl champion Philadelphia Eagles and AFC powerhouse Baltimore Ravens.
The NFL released the official schedule on Wednesday night, and the Bills found out when they’ll play every team on the slate.
The Bills open against the Baltimore Ravens on Sunday Night Football at home inside Highmark Stadium. That will be the last opening-day game in the building that opened in 1973. Buffalo will move across the street to its brand-new facility in 2026. The good news for the Bills is that all their heavyweight fights (Eagles, Chiefs, Ravens, & Bengals) are separated into different parts of the schedule.
The Bills do not have any true West Coast trips on the schedule, and the longest they have to travel is to Houston in Week 12.
Here are the five biggest takeaways from the 2025 Bills schedule release.
1. Early bye week blues
The Bills enjoyed a late bye week last season but will be forced to deal with a Week 7 bye in 2025. The early part of the schedule comes with loads of winnable games, but the Bills face five playoff teams after their bye. Road games against the Atlanta Falcons in Week 6 and the Carolina Panthers in Week 8 will be legitimate tests for the Bills before a Week 9 clash with the Chiefs. The Panthers got better down the stretch last season behind the improved play of quarterback Bryce Young. The Falcons have pushed all their chips to the middle of the table on second-year quarterback Michael Penix. The Bills play three divisional games before their bye, highlighted by night games against the Jets in Week 2 and the Patriots in
2. Close to home
Buffalo will travel 10,546 miles in 2025, the second-fewest of any team in the league. By comparison, the Los Angeles Chargers will travel the most miles this season at 37,086. The Bills weren’t selected as the away team in the eight International games.
The schedule lines up nicely with home and away contests. Buffalo only has two “road trips” in the year, with back-to-back trips to Houston and Pittsburgh in November and New England and Cleveland in December.
3. Patriots present early test
The Bills are the overwhelming favorite to win the AFC East in 2025, but keep an eye on the Patriots. New England hired Mike Vrabel as their new coach this offseason and had a solid draft, continuing to build around young quarterback Drake Maye. After the Ravens in the opener, a case can be made that the Patriots on Sunday Night Football in Week 5 is the toughest game the Bills will play until the Chiefs.
4. Ramp up for suspended players
New defensive additions Michael Hoecht and Larry Ogunjobi will miss the first six games of the season because they tested positive for performance-enhancing drugs this offseason. The Bills’ early schedule isn’t the most brutal stretch, and they should be able to survive without their new veteran d-linemen. The good news for the Bills is that both Hoecht and Ogunjobi get two games and a bye week to ramp up for their first rivalry game against the Chiefs.
5. Early primetime games
Four of the Bills’ five primetime games come in the season’s first six weeks. That makes preparations challenging for Bills coach Sean McDermott, who relies on his weekly routine to get his players ready to play. The Bills also play on a short week in Week 3 when they host the Dolphins off a road game in New Jersey. The Bills also played a good chunk of their primetime games before their bye last season. The primetime schedule ends when Buffalo plays Houston on Thursday Night Football in Week 12.