The San Francisco 49ers (6-4) visit the Arizona Cardinals (3-6) at State Farm Stadium in Glendale for a Week 11 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, November 16, including live updated odds and injury report news.
NameWeek 102025 SeasonJon Hoefling8-677-69-3Tyler Dragon8-676-70-3Blake Schuster7-772-61-3Lorenzo Reyes8-671-77-3Chris Bumbaca8-667-79-3Jordan Mendoza4-1057-60-2Richard MorinN/A25-12-1Cardinals vs. 49ers live odds, moneyline, over/under
Opening Lines
Spread: 49ers (-1.5)Moneyline: 49ers (-122), Cardinals (+102)Over/Under: 47.5
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Cardinals vs. 49ers picks against the spreadJon Hoefling: San Francisco 49ers (-2.5)
Given how poor the 49ers looked against Los Angeles, they’ll likely bounce back against a much weaker Cardinals squad.
Tyler Dragon: San Francisco 49ers (-2.5)
The Cardinals play teams tough and have an underrated defense, but the 49ers are exceeding expectations despite a plethora of injuries.
Christopher Bumbaca: San Francisco 49ers (-2.5)
The San Francisco 49ers have serious issues on defense. But I’m not buying the Jacoby Brissett narrative.
Lorenzo Reyes: San Francisco 49ers (-2.5)
It’s hard to have any confidence in Arizona right now, whether Kyler Murray or Jacoby Brissett is under center. I think the Niners win comfortably.
Jordan Mendoza: San Francisco 49ers (-2.5)
Arizona nearly had this team beaten earlier in the season. It won’t be as close this time around.
Blake Schuster: San Francisco 49ers (-2.5)
It says a lot about Arizona right now that the 49ers are this beat up and still favored on the road in a divisional matchup.
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