The Tampa Bay Buccaneers (6-3) visit the Buffalo Bills (6-3) at Highmark Stadium in Orchard Park for a Week 11 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, November 16, including live updated odds and injury report news.
NameWeek 102025 SeasonJon Hoefling8-677-69-3Tyler Dragon8-676-70-3Blake Schuster7-772-61-3Lorenzo Reyes8-671-77-3Chris Bumbaca8-667-79-3Jordan Mendoza4-1057-60-2Richard MorinN/A25-12-1Bills vs. Buccaneers live odds, moneyline, over/under
Opening Lines
Spread: Bills (-5.5)Moneyline: Bills (-238), Buccaneers (+200)Over/Under: 49.5
Get the edge with our exclusive NFL betting picks
Bills vs. Buccaneers picks against the spreadJon Hoefling: Buffalo Bills (-5.5)
The Bills won’t let their loss to Miami slide. They’re going to take it out on some poor, helpless pirates from Florida.
Tyler Dragon: Buffalo Bills (-5.5)
One of the best games of the week. Both teams are coming of a loss. Buffalo’s loss was perplexing, but I expect them to bounce back at home.
Christopher Bumbaca: Buffalo Bills (-5.5)
Big spread off a bad loss feels like another moment to fade the Bills. But not this time. Tampa Bay has more issues than we thought.
Lorenzo Reyes: Buffalo Bills (-5.5)
I think this is a prime bounce-back spot for the Bills, who may have fallen into a trap game in Miami. The Bucs are still injured, and the weather in Western New York looks like it will be cold, wet and windy.
Jordan Mendoza: Tampa Bay Buccaneers (+5.5)
This is going to be a fun one with both offenses putting on a show. Buffalo is getting too many points to trust it can make this a comfortable win.
Blake Schuster: Buffalo Bills (-5.5)
I know Bucky Irving won’t solve every problem in Tampa right now, but I can’t stop thinking about how much he adds to that offense. The Bucs need him back.
Bills vs. Buccaneers updated injury reportNFL Week 11 picks, predictions, oddsSuper Bowl 60 updated odds