The San Francisco 49ers (6-4) have a division matchup with the Arizona Cardinals (3-6) on Sunday, November 16, 2025 at State Farm Stadium.
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San Francisco 49ers vs. Arizona Cardinals game info
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San Francisco 49ers scheduleWeek 1: Sept. 7 at Seattle Seahawks, 17-13 winWeek 2: Sept. 14 at New Orleans Saints, 26-21 winWeek 3: Sept. 21 vs. Arizona Cardinals, 16-15 winWeek 4: Sept. 28 vs. Jacksonville Jaguars, 26-21 lossWeek 5: Oct. 2 at Los Angeles Rams, 26-23 winWeek 6: Oct. 12 at Tampa Bay Buccaneers, 30-19 lossWeek 7: Oct. 19 vs. Atlanta Falcons, 20-10 winWeek 8: Oct. 26 at Houston Texans, 26-15 lossWeek 9: Nov. 2 at New York Giants, 34-24 winWeek 10: Nov. 9 vs. Los Angeles Rams, 42-26 lossWeek 11: Nov. 16 at 4:05 p.m. ET at Arizona CardinalsWeek 12: Nov. 24 at 8:15 p.m. ET vs. Carolina PanthersWeek 13: Nov. 30 at 1 p.m. ET at Cleveland BrownsWeek 15: Dec. 14 at 4:25 p.m. ET vs. Tennessee TitansWeek 16: Dec. 22 at 8:15 p.m. ET at Indianapolis ColtsWeek 17: Dec. 28 at 8:20 p.m. ET vs. Chicago BearsWeek 18: TBD vs. Seattle Seahawks
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San Francisco 49ers statsTotal offense: 356.2 yards per game, 11th in NFLPassing offense: 261.4 yards per game, first in NFLRushing offense: 94.8 yards per game, 27th in NFLTotal defense: 339.4 yards per game, 21st in NFLPassing defense: 228.8 yards per game, 22nd in NFLRushing defense: 110.6 yards per game, 16th in NFLArizona Cardinals scheduleWeek 1: Sept. 7 at New Orleans Saints, 20-13 winWeek 2: Sept. 14 vs. Carolina Panthers, 27-22 winWeek 3: Sept. 21 at San Francisco 49ers, 16-15 lossWeek 4: Sept. 25 vs. Seattle Seahawks, 23-20 lossWeek 5: Oct. 5 vs. Tennessee Titans, 22-21 lossWeek 6: Oct. 12 at Indianapolis Colts, 31-27 lossWeek 7: Oct. 19 vs. Green Bay Packers, 27-23 lossWeek 9: Nov. 3 at Dallas Cowboys, 27-17 winWeek 10: Nov. 9 at Seattle Seahawks, 44-22 lossWeek 11: Nov. 16 at 4:05 p.m. ET vs. San Francisco 49ersWeek 12: Nov. 23 at 4:05 p.m. ET vs. Jacksonville JaguarsWeek 13: Nov. 30 at 1 p.m. ET at Tampa Bay BuccaneersWeek 14: Dec. 7 at 4:25 p.m. ET vs. Los Angeles RamsWeek 15: Dec. 14 at 1 p.m. ET at Houston TexansWeek 16: Dec. 21 at 4:05 p.m. ET vs. Atlanta FalconsWeek 17: TBD at Cincinnati BengalsWeek 18: TBD at Los Angeles Rams
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Arizona Cardinals statsTotal offense: 316.3 yards per game, 21st in NFLPassing offense: 202.9 yards per game, 21st in NFLRushing offense: 113.4 yards per game, 18th in NFLTotal defense: 339.4 yards per game, 21st in NFLPassing defense: 225.3 yards per game, 20th in NFLRushing defense: 114.1 yards per game, 18th in NFL
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