Bills vs. Buccaneers prediction, pick, odds for Sunday's NFL Week 11 game

Bills vs. Buccaneers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 3:19 p.m.

Moneyline (ML): Buffalo -250 (Bet $250 to win $100) | Tampa Bay +200 (Bet $100 to win $200)Against the spread (ATS): Buffalo -5.5 (-110) | Tampa Bay +5.5 (-110)Over/Under (O/U): 47.5 (O: -110 | U: -110)Bills vs. Buccaneers betting tips preview

The Tampa Bay Buccaneers (6-3) visit the Buffalo Bills (6-3) at Highmark Stadium on Sunday, November 16, 2025, and best bets information is available.

Last time out, the Bills fell short against the Miami Dolphins, 30-13. The Buccaneers fell short by a final score of 28-23 in their most recent outing, a matchup with the Patriots. In that last outing for the Bills, Josh Allen completed 28 of 40 passing attempts (70.0%) and totaled 306 yards through the air, completing two touchdown passes but giving away one interception. James Cook had 13 rushing attempts and wound up with 53 yards while also hauling in five receptions for 24 yards. Khalil Shakir ended the contest with seven catches for 58 yards.

For the Buccaneers in their last game, Baker Mayfield finished with 28 completions on 43 attempts (65.1%) for 273 yards, throwing three touchdowns. Sean Tucker carried the ball nine times for 53 yards. Emeka Egbuka snagged six passes for 115 yards with one touchdown.

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Bills vs. Buccaneers key injuriesBillsNo players are on the injury report as of 3:19 p.m. ET on Nov. 13.BuccaneersNo players are on the injury report as of 3:19 p.m. ET on Nov. 13.Bills vs. Buccaneers prediction

Buccaneers 25, Bills 24

Moneyline pick: Buccaneers +200The implied moneyline probability in this matchup gives the Bills a 71.4% chance to win.Buffalo is 4-3 in games they were listed as the moneyline favorite (winning 57.1% of those games).The Bills have gone 4-2 in games they have played as a moneyline favorite with odds of -250 or shorter (66.7%).This season, Tampa Bay has been the underdog four times and won two of those games.The Buccaneers have played as an underdog of +200 or more once this season and lost that game.Pick ATS: Buccaneers (+5.5)So far this season, Buffalo has put together a 4-5-0 record against the spread.The Bills have covered the spread twice this season when favored by 5.5 points or more (in six chances).Against the spread, Tampa Bay is 5-4-0 this season.The Buccaneers have been underdogs by 5.5 points or more one time this year and have not covered the spread once.Pick OU: Over (47.5)In five of nine games this season, the Bills and their opponents have combined to total more than 47.5 points.The Buccaneers have played five games this season that ended with a point total above 47.5 points.These two teams score 52 points per game between them, 4.5 more than this game’s over/under.Combined, these teams surrender 44.8 points per game, 2.7 fewer points than this matchup’s over/under.

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Bills vs. Buccaneers prediction, pick, odds for Sunday’s NFL Week 11 game

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