The San Francisco 49ers (6-4) visit the Arizona Cardinals (3-6) on Sunday, November 16, 2025 in matchup between NFC West rivals at State Farm Stadium. Arizona is a 3-point underdog. An over/under of 48.5 points has been set for this game.
Find insights on potential game props in this article, including team to score first and player prop bet insights.
49ers vs. Cardinals game odds
NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 7:41 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread: 49ers -3 (-110 to cover)Moneylines: 49ers -160, Cardinals +135Total: 48.5 points (Over: -110, Under: -110)Pick ATS: 49ers (-3)Pick OU: Under (48.5)Prediction:
49ers 25 – Cardinals 20First TD odds and insights
First TD odds: 49ers -130, Cardinals -102
The 49ers have scored the first TD in five of 10 games this season.In those five games, one of San Francisco’s scores came on the ground, and four in the air.Looking at only first quarters, the 49ers have scored four touchdowns, ranking 14th among all teams in that category.The Cardinals have scored the first touchdown four times in nine games.In those four games when Arizona notched the first TD, it threw for three and rushed for one.Looking at only first quarters, the Cardinals have scored three touchdowns, ranking 20th among all teams in that category.
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Christian McCaffrey player propsRushing yard prop: Over/under 68.5 yardsReceiving yard prop: Over/under 51.5 yardsChristian McCaffrey’s 62.6 rushing yards per game average in 2025 is 5.9 fewer than Sunday’s over/under.McCaffrey has hit the over on his rushing yards total twice in 10 opportunities this season.McCaffrey has a rushing touchdown in three of 10 games this year, including multiple rushing TDs once.Trey McBride player propsReceiving yard prop: Over/under 73.5 yardsTrey McBride’s 67 receiving yards per game average is 6.5 fewer than his prop bet total in Sunday’s matchup (73.5).McBride has hit the over on his prop bets for receiving yards in four of nine games this season (44.4%).In five of nine games this season, McBride has a receiving touchdown (and he has one game with multiple receiving TDs).Jacoby Brissett player propsPassing yard prop: Over/under 229.5 yardsRushing yard prop: Over/under 19.5 yardsJacoby Brissett’s per-game passing yardage average this season (186.3) is 43.2 passing yards fewer than Sunday’s over/under.Brissett has hit the over on his passing yard totals in each of his four games this season with a prop.Brissett has thrown for a touchdown four times this season in six games played, including multiple TD passes four times.