The San Francisco 49ers (6-4) will be monitoring eight players on the injury report, including Christian McCaffrey, heading into their Sunday, Nov. 16 matchup against the Arizona Cardinals (3-6) at State Farm Stadium, which starts at 4:05 p.m. ET.
Hunting for details about injured players on the 49ers and Cardinals? We’ve got you covered. Keep reading for the most up-to-date injury report data for this upcoming contest.
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49ers vs. Cardinals game infoDate: Sunday, November 16, 2025Time: 4:05 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: FOXLive stream: Fubo (Regional restrictions may apply)
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 2:44 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: 49ers (-3)Moneyline: 49ers (-165), Cardinals (+140)Total: 48.5 points49ers injury reportDeommodore Lenoir | DB (Questionable)Injury: CalfPractice status: Did not participate in practiceDefensive stats: 0.0 sacks | 3.0 TFL | 33 tackles | 1 INT | 3 PDsMac Jones | QB (-)Injury: KneePractice status: Full participation in practicePassing stats: 289-for-201 | 2,151 YDS | 13 TDs | 6 INTsBrock Purdy | QB (-)Injury: ToePractice status: Full participation in practicePassing stats: 73-for-48 | 586 YDS | 4 TDs | 4 INTsRicky Pearsall | WR (-)Injury: KneePractice status: Full participation in practiceReceiving stats: 29 TAR | 20 REC | 327 YDS | 0 TDsDee Winters | LB (-)Injury: KneePractice status: Full participation in practiceDefensive stats: 0.0 sacks | 5.0 TFL | 67 tackles | 0 INTs | 3 PDsAlfred Collins | DT (-)Injury: HipPractice status: Full participation in practiceTrent Williams | OT (-)Injury: RestPractice status: Full participation in practiceSeason stats: 4 GPChristian McCaffrey | RB (-)Injury: RestPractice status: Full participation in practiceRushing stats: 180 ATT | 626 YDS | 4 TDsReceiving stats: 90 TAR | 69 REC | 692 YDS | 4 TDsCardinals injury reportBaron Browning | OLB (Out)Injury: ConcussionPractice status: Did not participate in practiceWill Johnson | CB (Out)Injury: BackPractice status: Did not participate in practiceDefensive stats: 0.0 sacks | 0.0 TFL | 19 tackles | 0 INTs | 6 PDsJonah Williams | OL (Out)Injury: ShoulderPractice status: Did not participate in practiceSeason stats: 4 GPHayden Conner | OL (Out)Injury: KneePractice status: Limited participation in practiceMarvin Harrison Jr. | WR (Out)Injury: IllnessPractice status: Did not participate in practiceReceiving stats: 62 TAR | 34 REC | 525 YDS | 4 TDsMack Wilson | LB (Out)Injury: RibsPractice status: Did not participate in practiceDefensive stats: 0.0 sacks | 3.0 TFL | 60 tackles | 1 INT | 6 PDsDadrion Taylor-Demerson | S (Out)Injury: AnklePractice status: Did not participate in practiceDefensive stats: 0.0 sacks | 0.0 TFL | 34 tackles | 2 INTs | 5 PDsDarius Robinson | DL (Questionable)Injury: GroinPractice status: Limited participation in practiceBJ Ojulari | OLB (Questionable)Injury: KneePractice status: Limited participation in practiceWalter Nolen | DL (Questionable)Injury: KneePractice status: Limited participation in practiceDefensive stats: 1.0 sack | 2.0 TFL | 6 tackles | 0 INTs | 1 PDBam Knight | RB (Questionable)Injury: AnklePractice status: Limited participation in practiceRushing stats: 48 ATT | 157 YDS | 2 TDsKelvin Beachum | OL (Questionable)Injury: GroinPractice status: Limited participation in practiceSeason stats: 2 GPWill Hernandez | OL (Questionable)Injury: KneePractice status: Limited participation in practiceSeason stats: 2 GPEvan Brown | OL (-)Injury: FootPractice status: Full participation in practiceSeason stats: 4 GPCalais Campbell | DL (-)Injury: RestPractice status: Did not participate in practiceDefensive stats: 5.0 sacks | 8.0 TFL | 26 tackles | 0 INTs | 1 PDJosh Sweat | OLB (-)Injury: RestPractice status: Limited participation in practiceDefensive stats: 8.0 sacks | 10.0 TFL | 18 tackles | 0 INTs | 2 PDsXavier Weaver | WR (-)Injury: AnklePractice status: Full participation in practiceSeason stats: 2 GPMax Melton | CB (-)Injury: ConcussionPractice status: Full participation in practiceDefensive stats: 0.0 sacks | 1.0 TFL | 26 tackles | 0 INTs | 4 PDsBilal Nichols | DL (-)Injury: PersonalPractice status: Full participation in practice
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