Check out the injury report for the San Francisco 49ers (6-4), which features eight players (including Mac Jones), as the 49ers ready for their matchup versus the Arizona Cardinals (3-6) at State Farm Stadium, on Sunday, Nov. 16 at 4:05 p.m. ET.
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49ers vs Cardinals TV channel & game infoGame day: Sunday, November 16, 2025Game time: 4:05 p.m. ETLocation: Glendale, ArizonaStadium: State Farm StadiumTV channel: FOXLive stream: Watch on Fubo! (Regional restrictions may apply)
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49ers injury reportDeommodore Lenoir | DB (Questionable)Injury: CalfPractice Status: Did Not Participate In Practice2025 Defensive Stats: 0.0 Sacks | 3.0 Tackles for Loss | 33 Tackles | 1 Interception | 3 Passes DefendedMac Jones | QBInjury: KneePractice Status: Full Participation in Practice2025 Passing: 289-for-201 | 2,151 Yards | 13 Touchdowns | 6 InterceptionsBrock Purdy | QBInjury: ToePractice Status: Full Participation in Practice2025 Passing: 73-for-48 | 586 Yards | 4 Touchdowns | 4 InterceptionsRicky Pearsall | WRInjury: KneePractice Status: Full Participation in Practice2025 Receiving Stats: 29 Targets | 20 Receptions | 327 Yards | 0 TouchdownsDee Winters | LBInjury: KneePractice Status: Full Participation in Practice2025 Defensive Stats: 0.0 Sacks | 5.0 Tackles for Loss | 67 Tackles | 0 Interceptions | 3 Passes DefendedAlfred Collins | DTInjury: HipPractice Status: Full Participation in PracticeTrent Williams | OTInjury: RestPractice Status: Full Participation in Practice2025 Season Stats: 4 Games PlayedChristian McCaffrey | RBInjury: RestPractice Status: Full Participation in Practice2025 Rushing: 180 Attempts | 626 Yards | 4 Touchdowns2025 Receiving Stats: 90 Targets | 69 Receptions | 692 Yards | 4 Touchdowns49ers insightsThe 49ers’ offense has seen improved production over its last three games, tallying 25.0 points per game, compared to its season-long average of 22.0 points per contest.Turning our attention to yardage, San Francisco has tallied fewer total yards per game over its last three matchups (332.0) than it has averaged for the season (356.2).In the passing game, the 49ers have amassed fewer passing yards per game over their last three matchups (238.3) than they have averaged for the season (261.4).San Francisco is running for 94.8 yards per contest this season, but it has been a tad less effective on the ground over its last three matchups, averaging 93.7 rushing yards per game.49ers vs Cardinals odds
NFL odds courtesy of BetMGM. Odds updated Saturday at 5:31 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: 49ers (-3)Moneyline: 49ers (-172), Cardinals (+144)Total: 48.5 points
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