The San Francisco 49ers (6-4) will face off against NFC West rivals, the Arizona Cardinals (3-6), on Sunday, November 16, 2025 at State Farm Stadium. The 49ers are listed as favorites in this one, with the spread sitting at 3.5 points. An over/under of 48.5 points has been set for the contest.
In their last game, the Cardinals lost versus the Seattle Seahawks, 44-22.
In that matchup versus the Seahawks, Cards QB Jacoby Brissett completed 22 of 44 attempts for 258 yards, with two touchdowns and no interceptions.
The 49ers lost to the Los Angeles Rams, 42-26, in their most recent game.
Cardinals vs 49ers betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:59 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: San Francisco (-3.5)Moneyline: San Francisco (-191), Arizona (+158)Total: 48.5 pointsCardinals betting insightsArizona has covered the spread once at home, and is 1-3 overall there this season.The Cardinals have compiled a 5-4-0 record against the spread this season.Arizona is unbeaten ATS (1-0) as 3.5-point underdogs or more at home.The Cardinals are 3-1 ATS when playing as at least 3.5-point underdogs.This year, Arizona has hit the over in three of four games at home.Cardinals games have gone over the total five times this season.Cardinals leadersBrissett: 1,118 PASS YDS / 186.3 YPG / 60.9% / 8 TD / 1 INT / 19 CAR / 82 RUSH YDS / 1 TDEmari Demercado: 26 CAR / 233 YDS / 33.3 YPG / 0 TD / 6 REC / 52 YDS / 7.4 YPG / 1 TDBam Knight: 48 CAR / 157 YDS / 22.4 YPG / 2 TD / 8 REC / 65 YDS / 9.3 YPG / 0 TDTrey McBride: 61 REC / 603 YDS / 67 YPG / 6 TDMarvin Harrison Jr.: 34 REC / 525 YDS / 58.3 YPG / 4 TDMichael Wilson: 22 REC / 231 YDS / 25.7 YPG / 1 TDCardinals vs 49ers game infoDate: Sunday, November 16, 2025Time: 4:05 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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