Arizona Cardinals commit 17 penalties in loss to 49ers
Theo Mackie and Bob McManaman discuss the Arizona Cardinals’ 41-22 loss to the San Francisco 49ers at State Farm Stadium on Nov. 16, 2025.
The Jacksonville Jaguars and Arizona Cardinals play on Sunday, Nov. 23, at the Cardinals’ State Farm Stadium in a game on the NFL Week 12 schedule.
Which team will win the NFL Week 12 game?
Check out these NFL Week 12 picks and NFL Week 12 predictions for the game, which can be seen at 2:05 p.m. MST on CBS (stream with FUBO).
The Jaguars are a 2.5-point favorite over the Cardinals in NFL Week 12 odds for the game, courtesy of BetMGM Sportsbook.
Jacksonville is -150 on the moneyline, while Arizona is +125. The over/under (point total) is set at 47.5 points.
Watch Jaguars at Cardinals live on FUBO (free trial)
Jeremy Cluff writes: “The Cardinals have given up 85 points in their last two games. They won’t give up that many to Trevor Lawrence and the Jaguars, but they will give up more than they score.”
Bookies.com: Bet the Cardinals with the points vs Jaguars
Bill Speros writes: “The Jags took advantage of a warm Florida day and an early East Coast start to short-circuit the Chargers 35-6 Sunday. The Cardinals, meanwhile, dropped their 2nd straight NFC West game Sunday and 7th of their past 8 overall. They continued their surge toward irrelevance. Buried in that 41-22 loss to San Francisco was this garbage-time-driven stat line from Cardinals backup QB Jacoby Brissett: 47 for 57, 452 yards passing, 2 TDs and 2 INTs. The Jaguars remain unconvincing on the road.”
The site’s formula predicts that the Jaguars will win the NFL Week 12 game against the Cardinals.
ESPN: Jaguars have a 54.3% chance to beat Cardinals on Sunday
The site gives the Cardinals a 45.4% shot at winning the NFL Week 12 game, with the remaining percentage accounting for a tie.
Dimers: Cardinals 24, Jaguars 22
It writes: “After extensive simulations, our model gives the Jaguars a win probability of 42%, while the Cardinals have a win probability of 58%.”
Sportsnaut: Arizona Cardinals 28, Jacksonville Jaguars 24
Matt Johnson writes: “We tend to believe that the Jacksonville Jaguars’ win this past Sunday said a lot more about the Chargers’ offensive line than it does about this team. Both teams could also be missing key wide receivers, with Marvin Harrison Jr. (appendicitis) unlikely to suit up. What the Arizona Cardinals can do is attack a Jaguars defense that ranks bottom five in the league against tight ends, and we suspect Jonathan Gannon will be able to cause some issues for Trevor Lawrence.”
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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