James Cook will lead the Buffalo Bills (7-3) into their battle versus the Houston Texans (5-5) at NRG Stadium on Thursday at 8:15 p.m. ET.

The Bills head into the matchup after winning 44-32 over the Tampa Bay Buccaneers in their last game on Nov. 16. The Texans are coming off of a 16-13 win over the Tennessee Titans. Josh Allen had 317 yards on 19-of-30 passing (63.3%) for the Bills in that matchup against the Buccaneers, with three touchdowns and two interceptions. He also added six carries for 40 yards and three rushing touchdowns. Cook took 16 carries for 48 yards (3.0 yards per carry), while adding three receptions for 66 yards and one touchdown in the passing game. Tyrell Shavers recorded four receptions for 90 yards (averaging 22.5 per catch), while scoring one touchdown against the Buccaneers. Davis Mills’ performance for the Texans against the Titans included 26-of-41 passing for 274 yards, one touchdown and no interceptions. In that matchup, Woody Marks had an 18-carry, 44-yard game (2.4 yards per attempt). He also added one reception for seven yards. Nico Collins caught nine passes on 10 targets for 92 yards (10.2 yards per reception), and scored one touchdown.

In the story below, we’ll give you all the info you need to know about how to watch this matchup on Fubo.

Watch Buffalo Bills vs. Houston Texans on Fubo! (Regional restrictions may apply)

Bills vs. Texans game infoGame day: Thursday, November 20, 2025Game time: 8:15 p.m. ETLocation: Houston, TexasStadium: NRG StadiumTV channel: FOX (KRIV – Houston, TX)Live stream: Fubo (Watch Now!)Live stream: Amazon Prime (Watch Now!)

Watch Buffalo Bills vs. Houston Texans on Fubo! (Regional restrictions may apply)

Bills vs. Texans betting info

NFL odds courtesy of BetMGM Sportsbook. Odds updated Monday at 11:10 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Spread favorite: Bills (-5.5)Moneyline: Bills (-250), Texans (+200)Total: 43.5 points

Watch Buffalo Bills vs. Houston Texans on Fubo! (Regional restrictions may apply)