The Houston Texans (5-5) will look to upset the Buffalo Bills (7-3) on Thursday, November 20, 2025 at NRG Stadium. The Bills are listed as favorites in this one, with the spread sitting at 6 points. The over/under in the contest is set at 43.5 points.
The Texans won versus the Tennessee Titans in their most recent game, 16-13.
Against the Titans, Davis Mills completed 26 of 41 attempts for 274 yards, with one touchdown and no interceptions, for the Texans.
The Bills beat the Tampa Bay Buccaneers, 44-32, in their most recent contest.
Texans vs Bills betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 12:03 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Buffalo (-6)Moneyline: Buffalo (-289), Houston (+232)Total: 43.5 pointsTexans betting insightsAt home this year, Houston is 3-2 overall and 3-2 against the spread.The Texans have compiled a 4-6-0 record against the spread this season.In five home games this year, Houston has gone over the total once.This season, Texans games have hit the over three times.Texans leadersMills: 726 PASS YDS / 181.5 YPG / 60% / 3 TD / 1 INT / 10 CAR / 44 RUSH YDS / 1 TDNick Chubb: 99 CAR / 419 YDS / 41.9 YPG / 2 TD / 11 REC / 59 YDS / 5.9 YPG / 0 TDWoody Marks: 99 CAR / 348 YDS / 34.8 YPG / 2 TD / 16 REC / 190 YDS / 19 YPG / 2 TDNico Collins: 49 REC / 642 YDS / 71.3 YPG / 4 TDDalton Schultz: 51 REC / 489 YDS / 48.9 YPG / 1 TDXavier Hutchinson: 24 REC / 264 YDS / 29.3 YPG / 3 TDTexans vs Bills game infoDate: Thursday, November 20, 2025Time: 8:15 p.m. ETCity: Houston, TexasVenue: NRG StadiumTV channel: Amazon Prime VideoLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Prime Video
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