The New York Giants (2-9) head out to the Motor City to take on the Detroit Lions (6-4) this Sunday at Ford Field.

The game has significance as Big Blue has lost five straight games, and the Lions are sitting in third place in the NFC North.

Here are three matchups to focus on in Week 12.

Stopping the Big Three

The Giants have allowed 27.3 points per game this year and 28.3 over their last three. They are 29th in total defense, allowing 375.1 yards per contest, and are 27th in red zone defense, allowing touchdowns over 48 percent of the time.

They will face perhaps their biggest challenge of the season in the Lions, who score nearly 30 points per game on average, led by a dynamic trio of wide receiver Amon-Ra St.Brown and running backs Jahmyr Gibbs and David Montgomery.

The trio has all scored touchdowns in the same game on 10 occasions, the most by any trio in NFL history. The Lions are 10-0 in games where all three players score a touchdown.

Giants LB Brian Burns vs. Lions RT Penei Sewell

Brian Burns had two sacks last week against the Packers and now has 13 on the year. He’s second in the NFL behind Cleveland’s Myles Garrett (15). He has already set a new high for sacks in a season, and there are six games still remaining.

Sewell, a three-time Pro Bowler and a First Team All-Pro the past two seasons, is dealing with an ankle injury. He did not practice on Wednesday, although he did soldier through the Lions’ 16-9 Sunday night loss in Philadelphia.

If Sewell cannot go, Dan Skipper is likely to play in Sewell’s place, creating a huge opportunity for Burns.

Giants QB Jaxson Dart vs. Lions red zone defense

Jaxson Dart is still in the concussion protocol, so it remains to be seen if he’ll play in the game. As of Thursday morning, he was still wearing the red “non-contact” jersey, and the team was optimistic he would be cleared for duty.

Before Dart took over the reins from Russell Wilson, the Giants were scoring touchdowns on just 20 percent of their trips into the red zone. Under Dart, the average got significantly better (54 percent — 13 for 24).

The Lions have not been very good defensively in the red zone, allowing touchdowns 64.6 percent of the time, ranking them 25th in the league.