Rams vs. Buccaneers prediction, pick, odds for Sunday's NFL Week 12 game

Rams vs. Buccaneers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 9:20 p.m.

Moneyline (ML): Los Angeles -325 (Bet $325 to win $100) | Tampa Bay +260 (Bet $100 to win $260)Against the spread (ATS): Los Angeles -6.5 (-115) | Tampa Bay +6.5 (-105)Over/Under (O/U): 49.5 (O: -110 | U: -110)Rams vs. Buccaneers betting tips preview

The Los Angeles Rams (8-2) take a five-game winning streak into a matchup against the Tampa Bay Buccaneers (6-4) on Sunday, November 23, 2025 at SoFi Stadium, and we have best bets recommendations.

The Rams prevailed 21-19 last time out when they faced the Seattle Seahawks. The Buccaneers lost in their last outing by a final score of 44-32 against the Bills. Matthew Stafford finished with 130 yards on 15-28 passing (53.6%) in the Rams’ last game, tossing two touchdowns. Kyren Williams rushed for one touchdown while compiling 91 yards on 12 attempts. Puka Nacua earned 75 yards on seven receptions.

For the Buccaneers in their last game, Baker Mayfield completed 16 of 28 passing attempts (57.1%) and totaled 173 yards through the air, connecting on one touchdown pass but giving away one interception and one touchdown as a rusher. Sean Tucker had 19 rushing attempts and finished with 106 yards and two touchdowns while also hauling in two receptions for 34 yards and one touchdown. Sterling Shepard ended the contest with four catches for 54 yards.

Watch Los Angeles Rams vs. Tampa Bay Buccaneers on Fubo! (Regional restrictions may apply)

Rams vs. Buccaneers key injuriesRamsNo players are on the injury report as of 9:20 p.m. ET on Nov. 20.BuccaneersNo players are on the injury report as of 9:20 p.m. ET on Nov. 20.Rams vs. Buccaneers prediction

Rams 31, Buccaneers 17

Moneyline pick: Rams -325Based on this matchup’s moneyline, the Rams’ implied win probability is 76.5%.Los Angeles has an 8-1 record in games they were favored on the moneyline (winning 88.9% of those games).The Rams have a record of 2-1 when they have played as a moneyline favorite with odds of -325 or shorter (66.7%).Tampa Bay has been an underdog in five games this season and won two (40%) of those contests.The Buccaneers have not entered a game this season with longer moneyline odds than +260.Pick ATS: Rams (-6.5)Los Angeles has posted a 7-3-0 record against the spread this season.This season, the Rams have two against the spread wins in three games as a favorite of 6.5 points or more.Tampa Bay owns a record of 5-5-0 against the spread this year.Pick OU: Under (49.5)The Rams and their opponents have scored more than 49.5 combined points three times this season.The Buccaneers have played five games this season that ended with a combined score higher than 49.5 points.These two teams average a combined 52.4 points per game, 2.9 more points than this matchup’s over/under.These teams allow a combined 42.2 points per game, 7.3 fewer points than this contest’s over/under.

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Rams vs. Buccaneers prediction, pick, odds for Sunday’s NFL Week 12 game

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