A look at the opening odds and lines for the Cardinals’ Week 1 game against the Saints.
The Arizona Cardinals released their full 2025 regular-season schedule on Wednesday. They open the season on the road against the New Orleans Saints, a team not expected to be very good in 2025.
Quarterback Derek Carr retired from the NFL after he was going to miss the entire season anyway with should surgery.
Their quarterbacks are rookie Tyler Shough, drafted in the second round, Spencer Rattler, who went 0-6 as a starter in 2024, and Jake Haener, who went 0-1 in one start last season as a rookie.
DraftKings Sportsbook released the opening line for this matchup, as well as the lines and odds for all the games on the 2025 NFL schedule.
The Cardinals, not surprisingly, are favored.
Cardinals at Saints Week 1 betting odds and lines
These are the odds and lines for the Cardinals at Saints Week 1 game that kicks off Sunday, Sept. 7 at 1 p.m. ET.
Moneyline:
Cardinals -192 (bet $192 to win $100)Saints +160 (bet $100 to win $160)
At -192 odds, the Cardinals have 65.75% implied odds of winning and are implied to be about 27% more likely to win the game than the Saints.
Spread (ATS)
Cardinals -3.5 (-115)Saints +3.5 (-105)
Right now, to win a spread bet on the Cardinals, they would need to win by four or more points. They are seen as slightly more likely to win by at least four than not to.
Total (Over/Under)
Over 43.5 (-115)Under 43.5 (-105)
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