The Carolina Panthers (6-5) will attempt to defy oddsmakers when they take on the San Francisco 49ers (7-4) on Monday, November 24, 2025 as a 7-point underdog.

49ers vs. Panthers game infoGame day: Monday, November 24, 2025Game time: 8:15 p.m. ETTV channel: ESPNLocation: Santa Clara, CaliforniaStadium: Levi’s StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)

Watch San Francisco 49ers vs. Carolina Panthers on Fubo! (Regional restrictions may apply)

49ers vs. Panthers odds & betting linesSpread favorite: San Francisco (-7)Moneyline: San Francisco (-364), Carolina (+288)Total: 49.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Friday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

49ers vs. Panthers recent matchupsIn the last three meetings between the 49ers and Panthers, San Francisco has gone 2-1.San Francisco has had the upper hand scoring in those three matchups, totaling 91 points against Carolina’s 51.49ers vs. Panthers betting insightsSan Francisco has six wins against the spread so far this season (6-5-0). In the seven games this season the 49ers have been the moneyline favorite, they have recorded a 6-1 record. Carolina has won seven games against the spread this season (7-4-0). The Panthers are 6-4 in games they have played as an underdog on the moneyline.49ers scoring insightsThe 49ers are averaging fewer points at home (20.8) than on the road (25.4).On defense, San Francisco’s average at home, 23.3 points conceded, is a tad worse than its average on the road, 22.7.The 49ers have put up 25.2 points per game in the division, which is better than their average in non-division games of 22.5.San Francisco is conceding 23.0 points per game in divisional matchups, which is slightly worse than its 22.8 average in non-division games.While the 49ers’ defense ranks fourth-worst in points allowed per game over the last three games (29.3), they rank best on the offensive side of the ball (33.7 points per game) over that stretch.Panthers scoring insightsAt home, the Panthers put up 20.6 points per game, higher than their 17.3 average on the road.On defense, Carolina is allowing 21.6 points per game at home, better than its 23.5 average on the road.Offensively, the Panthers average more points in division games (22.3) than against the rest of the league (17.5).Carolina is conceding 14.7 points per game in divisional matchups, which is lower than its 25.6 average outside the division.In their past three games, the Panthers are putting up 17.7 points per game (24th in NFL), and allowing 19.0 (seventh).49ers injury report49ers:
Dee Winters: Full Participation in Practice (Knee),
Trent Williams: Full Participation in Practice (NIR – Rest),
Curtis Robinson: Full Participation in Practice (Elbow),
Brock Purdy: Full Participation in Practice (Toe),
Eddy Pineiro: Did Not Participate In Practice (Hamstring),
Ricky Pearsall: Full Participation in Practice (Knee),
Christian McCaffrey: Full Participation in Practice (NIR – Rest),
Luke Gifford: Limited Participation in Practice (Hip),
Tatum Bethune: Did Not Participate In Practice (Ankle),
Robert Beal: Did Not Participate In Practice (Concussion)Panthers injury reportPanthers:
Cade Mays: Full Participation in Practice (Ankle),
Akayleb Evans: Limited Participation in Practice (Ankle),
Lathan Ransom: Full Participation in Practice (Hand),
Xavier Legette: Full Participation in Practice (Hip),
Tetairoa McMillan: Full Participation in Practice (Ankle),
Bryce Young: Full Participation in Practice (Ankle),
Tershawn Wharton: Full Participation in Practice (Knee),
Trevin Wallace: Did Not Participate In Practice (Shoulder),
Christian Rozeboom: Did Not Participate In Practice (Hip)

Watch San Francisco 49ers vs. Carolina Panthers on Fubo! (Regional restrictions may apply)