The Chiefs-Colts showdown comes at a pivotal moment for both clubs. Kansas City sits at 5-5 and needs a stabilizing win to stay in the AFC hunt after a stretch of uneven performances. Indianapolis enters at 8-2 with confidence, leaning on a strong ground game built around Jonathan Taylor and a steady hand from Daniel Jones in Shane Steichen’s system. The Colts have been one of the league’s most productive offenses, using their line to control the pace and keep defenses on their heels.
Kansas City still has the firepower to change a game quickly with Patrick Mahomes and Travis Kelce, but the Chiefs haven’t found reliable rhythm, especially on the ground. Their defense remains athletic and capable, yet this matchup will push them to stay disciplined against a balanced Colts attack that forces opponents into uncomfortable spots. With Kansas City fighting to stay in the playoff mix and Indianapolis looking to tighten its hold near the top of the AFC, this meeting projects as a tough, methodical battle rather than a track meet.
Bet365 introduced a new set of boosted parlays for Sunday’s Colts–Chiefs game, featuring touchdown props, yardage targets, and quarterback-focused angles from both sides. The offerings highlight the amount of firepower in this matchup and give bettors several ways to back the players most capable of swinging momentum in a single series.
New NFL Week 12 odds boosts for Patrick Mahomes, Jonathan Taylor, and more
Bet365 features a fresh set of Bet Boost parlays for Sunday’s Colts-Chiefs matchup, highlighting touchdown scorers, yardage milestones, and quarterback production.
TD Stack
legs: Rashee Rice to score a TD; Jonathan Taylor to score a TD; Travis Kelce to score a TD; Michael Pittman Jr. to score a TDOdds were: +2100, Boosted to: +2500
QB Duel
legs: Daniel Jones 2+ pass TDs; Patrick Mahomes 2+ pass TDs; Alec Pierce to score a TD; Xavier Worthy to score a TDOdds were: +1100, Boosted to: +1200
Mahomes in Motion
legs: Patrick Mahomes 300+ pass yards; Patrick Mahomes 30+ rush yards; Patrick Mahomes 3+ pass TDsOdds were: +750, Boosted to: +850
Trusty Hands
legs: Rashee Rice 70+ receiving yards; Alec Pierce 60+ receiving yards; Travis Kelce 50+ receiving yards; Michael Pittman Jr. 40+ receiving yards; Tyler Warren 30+ receiving yards; Marquise Brown 20+ receiving yardsOdds were: +1250, Boosted to: +1400
JT for MVP
legs: Colts moneyline; Jonathan Taylor 150+ rush yards; Jonathan Taylor to score a TDOdds were: +1250, Boosted to: +1400
Rice to the Occasion
legs: Chiefs moneyline; Rashee Rice 100+ receiving yards; Rashee Rice to score a TDOdds were: +525, Boosted to: +600
These boosted parlays give bettors creative angles on a high-profile AFC showdown with plenty of star-driven upside.
Indianapolis Colts running back Jonathan Taylor (28) plays during the first half of an NFL football game against the Buffalo Bills in Orchard Park, N.Y., Sunday, Nov. 21, 2021.APMatchup OverviewDate: Sunday, November 23, 2025Time: 1:00 PM ETVenue: GEHA Field at Arrowhead StadiumNFL stats, rosters and injury reportsOddsSpread: Chiefs favored at -3.5Total (Over/Under): 50Moneyline Odds: Colts +156, Chiefs -175
Note: The NFL odds in this article are correct at time of publication and subject to change.
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Dimers’ 10,000-game simulation gives Kansas City a 62 percent chance to win, with Indianapolis at 38 percent. The model projects a tight game built around efficient quarterback play and red-zone execution.
The predicted final score is Chiefs 27, Colts 23, reflecting Kansas City’s slight edge in offensive upside and home-field advantage. Patrick Mahomes’ projected output gives the Chiefs a reliable foundation, while Jonathan Taylor and the Colts ground game keep things competitive deep into the fourth quarter.
Best Bet: Chiefs Moneyline (-175)
Kansas City holds the higher win probability, and the gap in quarterback play and turnover margin favors the Chiefs at home. With Mahomes projected to outgain Daniel Jones through the air and the Chiefs receiving corps graded for higher explosive-play potential, the moneyline offers the safest angle on this matchup.
Projected Player Stats: Chiefs vs. ColtsQuarterbacksTeamPlayerProjected Pass YardsColtsDaniel Jones242ChiefsPatrick Mahomes274Colts RushingPlayerTD %Projected YardsJonathan Taylor69%87Daniel Jones24%24A. Abdullah7%8Chiefs RushingPlayerTD %Projected YardsIsiah Pacheco40%37Patrick Mahomes22%26Kareem Hunt39%17Colts ReceivingPlayerTD %Projected YardsAlec Pierce24%58Michael Pittman Jr.26%56Tyler Warren28%52Josh Downs22%41Jonathan Taylor69%20Chiefs ReceivingPlayerTD %Projected YardsRashee Rice46%77Travis Kelce36%51Xavier Worthy29%47Hollywood Brown22%28JuJu Smith-Schuster13%16$365 Bet365 Missouri Bonus Code Now Live for Pre-Launch: 
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Kansas City enters this matchup with the stronger simulation profile, more dependable quarterback play, and home-field advantage. The projected numbers point to an efficient afternoon for Mahomes and a balanced supporting cast, while the Colts rely on Jonathan Taylor and timely throws from Daniel Jones to keep pace. With Dimers giving Kansas City the clear probability edge and Bet365 Bet Boost parlays featuring several star-focused parlays for this game, this AFC showdown sets up as an exciting but slightly Chiefs-leaning contest.
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