Check out best bets for when the San Francisco 49ers (7-4) and the Carolina Panthers (6-5) play at Levi’s Stadium on Monday, November 24, 2025.
Watch San Francisco 49ers vs. Carolina Panthers on Fubo! (Regional restrictions may apply)
Best 49ers vs. Panthers against the spread pickPick ATS: 49ers (-7.5)San Francisco has gone 6-5-0 ATS this season.Carolina has seven wins against the spread in 11 games this season.This year, the Panthers won ATS in their only game as an underdog of 7.5 points or more.Best 49ers vs. Panthers over/under pickPick OU: Under (49.5)The 49ers and their opponents have scored more than 49.5 points in three of 11 games this season.The Panthers have played four games this season that ended with a combined score above 49.5 points.These two teams average a combined 42.5 points per game, seven fewer points than this matchup’s total.Opponents of these teams average 45.5 points per game combined, four fewer than this matchup’s total.Best 49ers vs. Panthers moneyline betMoneyline pick: 49ers -375The 49ers have a 78.9% chance to win this matchup based on the moneyline’s implied probability.San Francisco is 6-1 in games they were favored on the moneyline (winning 85.7% of those games).The 49ers have yet to play as a moneyline favorite of -375 or shorter.Carolina has entered the game as an underdog 10 times this season and won six of those games.The Panthers have entered two games this season as the underdog by +300 or more and are 1-1 in those contests.How to watch 49ers vs. PanthersWhen: Monday, November 24, 2025 at 8:15 p.m. ETWhere: Levi’s Stadium in Santa Clara, CaliforniaTV info: ESPNLive stream: Watch on Fubo! (Regional restrictions may apply)
Watch San Francisco 49ers vs. Carolina Panthers on Fubo! (Regional restrictions may apply)