The Carolina Panthers (6-5) will work to prove oddsmakers wrong when they hit the field against the San Francisco 49ers (7-4) on Monday, November 24, 2025 as a 7.5-point underdog. The game’s point total is listed at 49.5.
Find insights on potential game props for parlays below in this article, including first to score and prop bets for the top players.
49ers vs. Panthers game odds
NFL odds courtesy of BetMGM Sportsbook. Odds updated Sunday at 1:43 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread: 49ers -7.5 (-105 to cover)Moneylines: 49ers -375, Panthers +300Total: 49.5 points (Over: -110, Under: -110)Pick ATS: 49ers (-7.5)Pick OU: Under (49.5)Prediction:
49ers 29 – Panthers 15First TD odds and insights
First TD odds: 49ers -200, Panthers +145
The 49ers have scored the first touchdown six times this year out of 11 games played.In those six games, two of San Francisco’s scores came rushing the ball, and four in the air.Looking at the first quarter only, the 49ers have put six touchdowns on the board, 11th among all teams.The Panthers have scored the opening touchdown in six games out of the 11 they’ve played so far.In those six games when Carolina scored the first TD, it rushed for three and passed for three.Looking at just first quarters, the Panthers have scored four touchdowns, ranking 17th among all teams in that category.
Watch San Francisco 49ers vs. Carolina Panthers on Fubo!
Christian McCaffrey player propsRushing yard prop: Over/under 75.5 yardsReceiving yard prop: Over/under 43.5 yardsChristian McCaffrey racks up 64.3 rushing yards per game this season, which falls short of Monday’s over/under of 75.5 yards.McCaffrey hit the over on his rushing yards total set by oddsmakers in three of his 11 opportunities this season (27.3%).McCaffrey has scored at least once on the ground four times this year, with multiple rushing TDs in two of those contests.Rico Dowdle player propsRushing yard prop: Over/under 76.5 yardsReceiving yard prop: Over/under 16.5 yardsRico Dowdle racks up 75.7 rushing yards per game this season, which falls shy of Monday’s over/under of 76.5 yards.So far this season, Dowdle has hit the over six times on his rushing yards prop bet (in 11 opportunities).Dowdle has a rushing touchdown in four of 11 games this season, including multiple rushing TDs once.Bryce Young player propsPassing yard prop: Over/under 209.5 yardsRushing yard prop: Over/under 6.5 yardsBryce Young has thrown for an average of 196.2 yards per game this season, 13.3 fewer than Monday’s over/under.Young has hit the over on his passing yard totals in three games this season (30.0% of total opportunities).Young has a passing touchdown in seven of 10 games this season, with multiple passing TDs in four of them.