The San Francisco 49ers (7-4) play the Carolina Panthers (6-5) on Monday, November 24, 2025 at Levi’s Stadium. The 49ers are considerable favorites in this one, with the spread sitting at 7.5 points. The over/under in the outing is set at 49.5 points.
The Panthers beat the Atlanta Falcons, 30-27, in their most recent game.
Panthers quarterback Bryce Young went 31-for-45 for 448 yards, with three TDs and no INTs, against the Falcons.
Last time around, the 49ers defeated the Arizona Cardinals, with 41-22 being the final score.
Panthers vs 49ers betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Monday at 1:27 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: San Francisco (-7.5)Moneyline: San Francisco (-385), Carolina (+303)Total: 49.5 pointsPanthers betting insightsThis year in away games, Carolina is 4-2 against the spread and 3-3 overall.The Panthers have covered the spread seven times in 11 games with a set spread.Carolina is unbeaten ATS (1-0) as 7.5-point underdogs or more away from home.The Panthers are a perfect 1-0 ATS when playing as at least 7.5-point underdogs.Carolina has gone over the total in three of six road games this year.Games involving Panthers have hit the over six times this year.Panthers leadersYoung: 1,962 PASS YDS / 196.2 YPG / 62.7% / 14 TD / 7 INTRico Dowdle: 168 CAR / 833 YDS / 75.7 YPG / 5 TD / 23 REC / 197 YDS / 17.9 YPG / 1 TDChuba Hubbard: 91 CAR / 334 YDS / 37.1 YPG / 1 TD / 17 REC / 126 YDS / 14 YPG / 2 TDTetairoa McMillan: 54 REC / 748 YDS / 68 YPG / 4 TDXavier Legette: 24 REC / 264 YDS / 29.3 YPG / 3 TDPanthers vs 49ers game infoDate: Monday, November 24, 2025Time: 8:15 p.m. ETCity: Santa Clara, CaliforniaVenue: Levi’s StadiumTV channel: ESPNLive stream: Watch on Fubo (Regional restrictions may apply)
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