The San Francisco 49ers (7-4) host the surprising Carolina Panthers (6-5) in a key Monday Night Football matchup. This game features NFC playoff implications as NFL week 12 wraps up in primetime. Christian McCaffrey leads the Niners in this one against his former team, and DraftKings sports an intriguing Anytime touchdown prop for this ballgame.

DraftKings Featured Prop: Christian McCaffrey Anytime TD (-130)

DraftKings offers odds of -130 on Christian McCaffrey to score a touchdown anytime against the Panthers on Monday Night Football.

McCaffrey enters as the top red-zone option for San Francisco, earning 41 rushing attempts (third-most) and scoring six rushing touchdowns so far this season.His 14 receptions and 18 targets in the red-zone lead all running backs in 2025. Dimers’ predictive model gives McCaffrey a 69.1% probability of scoring, making this prop a strong value compared to the implied odds.The Carolina run defense has surrendered nine rushing touchdowns to running backs this season, including six over the last four weeks (tied for most in the NFL).

Note: Odds in this article are correct at time of publication and subject to change.

Game Details: Panthers vs. 49ersDate: Monday, November 24, 2025Time: 8:15 PM ETVenue: Levi’s StadiumSpread: 49ers favored at -7.5Total (Over/Under): 49.5Moneyline Odds: Panthers +320, 49ers -375NFL stats, rosters and injury reportsExpert Prediction: Panthers vs. 49ers

Dimers’ model has simulated Monday night’s Panthers vs. 49ers matchup 10,000 times and gives San Francisco a strong edge. The 49ers win 75% of simulations, while Carolina comes in at 25%.

Dimers’ projected final score is 49ers 29, Panthers 21, based on each team’s average performance and player-level projections across all simulations.

Best Bet: Panthers vs. 49ers

The strongest betting angle for Monday night might be 49ers -7.5. San Francisco’s offense grades out with clear advantages at quarterback, rushing efficiency, and red-zone touchdown probability. Their defensive pressure metrics also create matchup issues for a Carolina team that has struggled to produce consistent explosive plays.

NFL Player Props: Panthers vs. 49ers

Below are the top Anytime Touchdown, First Touchdown, and Box Score Leader projections for each team, using Dimers’ probability tables and statistical simulations.

San Francisco 49ersTop Anytime Touchdown ScorersChristian McCaffrey — 69.1%George Kittle — 41.6%Jauan Jennings — 32.0%Top First Touchdown ScorersChristian McCaffrey — 19.0%George Kittle — 8.7%Jauan Jennings — 6.2%Projected Box Score LeadersPassing Yards: Brock Purdy — 256 yardsReceiving Yards: George Kittle — 58 yardsRushing Yards: Christian McCaffrey — 73 yardsCarolina PanthersTop Anytime Touchdown ScorersRico Dowdle — 50.5%Tetairoa McMillan — 35.2%Xavier Legette — 21.0%Top First Touchdown ScorersRico Dowdle — 11.8%Tetairoa McMillan — 7.3%Xavier Legette — 4.0%Projected Box Score LeadersPassing Yards: Bryce Young — 216 yardsReceiving Yards: Tetairoa McMillan — 69 yardsRushing Yards: Rico Dowdle — 76 yardsConclusion: 49ers vs. Panthers on MNF

Monday night sets up as a favorable spot for San Francisco, with Dimers’ simulations and matchup data pointing toward a multi-score advantage built on efficiency and playmakers who consistently finish drives. Carolina has a few prop angles worth monitoring, but the 49ers hold the clearer path to control the game on both sides of the ball. Backing San Francisco and leaning on the strongest projections offers the most reliable approach for this matchup.

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