The San Francisco 49ers‘ huge slate of four games began in Week 11 with a victory over the Arizona Cardinals. It continues Monday night vs. the Carolina Panthers in San Francisco’s return to Levi’s Stadium.

If the 49ers win they plant themselves firmly in the postseason picture where a couple more wins should get them into the tournament in January. A win also pushes the Panthers further out of the picture since they’re only one game behind the 49ers entering Monday’s game. San Francisco would take a two-game lead on Carolina while also holding the crucial head-to-head tiebreaker.

Conversely, a loss would be extremely damaging. It would be an NFC loss that drops the 49ers out of the top seven and puts them in a tie with Carolina where the Panthers hold the tiebreaker. Winning NFC games is helpful for tiebreakers and the 49ers hold a strong 7-2 record inside the conference.

Niners Wire is bringing you live updates, scores and highlights from the game. Follow along.

How to watch 49ers vs. Panthers

What time does 49ers vs. Panthers start?  Date: Monday, November 23Time: 5:15 pm PTWhere: Levi’s Stadium, Santa Clara, Calif.What TV channel is 49ers vs. Panthers on today?  49ers vs. Panthers predictionsOnly four out of 43 experts in our list of expert picks selected the Panthers to win. If the 49ers approach Monday’s game with the proper urgency, it should be a game they win comfortably. They’ll sell out to stop the run and force Bryce Young to beat them from muddy pockets. Carolina may put a couple of drives together, but it’s tough to see the Panthers stopping the 49ers’ offense given their injuries at linebacker and struggles in coverage at that position. 49ers 31, Panthers 2449ers injury updates for Monday Night FootballDE Robert Beal (concussion), OutLB Tatum Bethune (ankle), OutLB Luke Gifford (hip, neck), QuestionableK Eddy Pineiro (hamstring), Out

Beal was downgraded to ‘out’ after originally being listed as ‘doubtful’ with a concussion he suffered in Week 11.

49ers schedule 2025

Here is San Francisco’s regular season schedule and results.

Sunday, Sept. 7: 49ers 17, Seahawks 13Sunday, Sept. 14: 49ers 26, Saints 21Sunday, Sept. 21: 49ers 16, Cardinals 15Sunday, Sept. 28: Jaguars 26, 49ers 21Thursday, Oct. 2: 49ers 26, Rams 23Sunday, Oct. 12: Buccaneers 30, 49ers 19Sunday, Oct. 19: 49ers 20, Falcons 10Sunday, Oct. 26: Texans 26, 49ers 15Sunday, Nov. 2: 49ers 34, Giants 24Sunday, Nov. 9: Rams 42, 49ers 26Sunday, Nov. 16: 49ers 41, Cardinals 22Monday, Nov. 24: 49ers vs. PanthersSunday, Nov. 30: 49ers at BrownsSunday, Dec. 7: ByeSunday, Dec. 14: 49ers vs. TitansMonday, Dec. 22: 49ers at ColtsSunday, Dec. 28: 49ers vs. BearsSunday, Jan. 4: 49ers vs. Seahawks

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