Published Nov 26, 2025 • 21 mins ago
Mark J. Rebilas-Imagn Images
The above videos are auto-populated by an affiliate.
The San Francisco 49ers got a win over the Carolina Panthers on Monday night, but the victory came with a setback. Defensive end Sam Okuayinonu left the game with an ankle injury and did not return. By Wednesday, the team provided an update on his status.
Head coach Kyle Shanahan told reporters ahead of practice that Okuayinonu is expected to miss multiple weeks after suffering a high-ankle sprain.
“It’s going to be at least a couple of weeks—high-ankle sprain. So, it’s going to be some time,” Shanahan said.
Okuayinonu’s absence adds to an already depleted defensive front that has lost key contributors, including veterans Nick Bosa and Yetur Gross-Matos, as well as rookie Mykel Williams.
Additionally, the 49ers do not expect the following players to practice:
Linebacker Luke Gifford will practice but be a limited participant due to hip and neck issues.
Follow us on:
Nobody’s perfect. Did you find a mistake in this article? Report it.
Click here and check the box by our name!
Comments
Do not use the comments to notify us of errors in the article. Editors may not see it. Instead, report errors here.
Read Next
49ers injury updates: Bethune, Piñeiro expected to miss time; No Aiyuk this week
49ers injury updates: Bethune, Piñeiro expected to miss time; No Aiyuk this week
San Francisco 49ers head coach Kyle Shanahan spoke with reporters during a Monday conference call, one day after the team’s 41-22 win over the Arizona Cardinals. He also shared several injury updates from the game.
Linebacker Tatum Bethune suffered a high-ankle sprain and is…
49ers vs. Cardinals injury updates: Multiple defenders exit the game
49ers vs. Cardinals injury updates: Multiple defenders exit the game
The San Francisco 49ers are facing the Arizona Cardinals at State Farm Stadium in Week 11. Below are the latest in-game injury updates for the 49ers. This article will be updated in real time as new information becomes available.
Players are listed in order of most recent…
49ers vs. Panthers injury report: 5 players miss Thursday’s practice
49ers vs. Panthers injury report: 5 players miss Thursday’s practice
The San Francisco 49ers are preparing for their Week 12 contest against the Carolina Panthers on Monday at Levi’s Stadium in Santa Clara, California.
There were no surprises in Wednesday’s practice participation report. Head coach Kyle Shanahan had already stated that…
49ers vs. Panthers injury report: Who missed practice ahead of key Week 12 matchup
49ers vs. Panthers injury report: Who missed practice ahead of key Week 12 matchup
The San Francisco 49ers are preparing for their Week 12 contest against the Carolina Panthers on Monday at Levi’s Stadium in Santa Clara, California.
There were no significant changes to Friday’s practice lineup compared to Thursday’s session. Running back Christian McCaffrey…