Ohio State and Michigan meet Saturday in a matchup loaded with national stakes. The Buckeyes enter undefeated and balanced on both sides of the ball, while the Wolverines arrive at 9–2 after handling Maryland last week. With playoff positioning hanging in the balance, both teams know this edition of The Game will likely determine their postseason path. The rivalry always carries weight, but the magnitude feels even heavier this time with both defenses playing at a high level and each offense capable of stretching the field.
Injuries have shaped much of the buildup. Michigan fullback and captain Max Bredeson left the Maryland game on crutches, but he said he feels good and expects to play. Running back Jordan Marshall has been cleared after a shoulder issue, and wideout Semaj Morgan is also trending toward suiting up, though safety Rod Moore is out for the season. Ohio State expects to get help at receiver, as Jeremiah Smith and Carnell Tate have both returned to work after missing time. Coaches still list them as day to day, but Smith said he feels ready and plans to be available for Saturday.
Ohio State vs. Michigan betting preview
Utilize the interactive widget below to discover the latest spread, total, and moneyline betting odds and probabilities for the Buckeyes-Wolverines game at Michigan Stadium.
This prediction and best bet for Saturday’s college football matchup between Ohio State and Michigan is from Dimers.com, a reliable source for sports betting predictions.
Game DetailsDate:Â Saturday, November 29, 2025Time:Â 12:00 PM ETVenue:Â Michigan StadiumNCAAF rankings:Â Updated AP Top 25College football news:Â Check the latest updates from the official NCAA football news siteOddsSpread:Â Ohio State favored at -10Total (Over/Under):Â 43.5Moneyline Odds:Â Ohio State -400, Michigan +320
The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.
Ohio State quarterback Will Howard plays against Michigan during an NCAA college football game Saturday, Nov. 30, 2024, in Columbus, Ohio.APExpert Prediction: Ohio State vs. Michigan
Dimers’ simulations point toward a competitive game that leans in Ohio State’s favor. After 10,000 simulated outcomes, the model projects a 28–18 Ohio State win. The Buckeyes carry a 77 percent win probability, while Michigan sits at 23 percent. The Wolverines have won five straight in this rivalry, but the analytics show Ohio State entering Saturday with the stronger overall profile, especially on defense.
Best Bet: Michigan +10
Despite the model favoring the Buckeyes, the spread gives Michigan enough cushion to stay inside the number. The Wolverines have covered consistently in this matchup during their five-game streak, and their ability to shorten the game with the run might make Michigan +10 the best value on the board.
Top Player Props: OSU vs. MichiganPlayer / PropProbabilityEdgeBest OddsAndrew Marsh Over 52.5 Receiving Yards (Michigan)76.8%23.6%-114Bo Jackson Over 77.5 Rushing Yards (Ohio State)67.7%14.6%-113Jeremiah Smith Anytime TD (Ohio State)62.2%4.0%-139Jordan Marshall Anytime TD (Michigan)58.8%7.6%-105Bryce Underwood Over 154.5 Passing Yards (Michigan)56.6%3.3%-114Conclusion: Ohio St vs. Michigan
Dimers’ numbers expect Ohio State to control most of the game, but Michigan’s recent dominance in the rivalry and its ability to grind possessions make the Wolverines a strong play at +10. Player props also show several high-value opportunities, with Andrew Marsh, Bo Jackson, and Jeremiah Smith standing out. Saturday’s matchup should bring another intense chapter to college football’s biggest rivalry.
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