Oddsmakers project the Houston Texans (6-5) to put up a fight in their attempt to prolong their three-game winning streak, as they are just 3.5-point underdogs in a matchup against the Indianapolis Colts (8-3) on Sunday, November 30, 2025 at Lucas Oil Stadium.

Colts vs. Texans game infoGame day: Sunday, November 30, 2025Game time: 1 p.m. ETTV channel: CBSLocation: Indianapolis, IndianaStadium: Lucas Oil StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)Live stream: Watch this game on Paramount+ (Regional restrictions may apply)

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Colts vs. Texans odds & betting linesSpread favorite: Indianapolis (-3.5)Moneyline: Indianapolis (-194), Houston (+162)Total: 44.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 2:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Colts vs. Texans recent matchupsOver the last five matchups between Indianapolis and Houston, the Texans are 4-1.The Colts have a 3-2 record against the spread in those games versus the Texans, and the two team outpaced the point total on three occasions.Indianapolis totaled 128 points in those five matchups, with Houston putting up 127.Colts vs. Texans betting insightsIndianapolis is 7-4-0 against the spread through 11 opportunities so far this season. In the seven games this season the Colts have been the moneyline favorite, they have put together a 6-1 record. Houston is 5-6-0 against the spread this season. In the four games this year, the Texans have been an underdog on the moneyline, they are 1-3.Colts scoring insightsThe Colts are averaging more points at home (33.7) than away (27.8).Defensively, Indianapolis is giving up 18.0 points per game at home, less than its 24.2 average away from home.Over the Colts’ last three games, they rank 15th in scoring offense (23.7 points per game) and 26th in scoring defense (25.0 points per game surrendered).Texans scoring insightsAt home, the Texans put up 24.2 points per game, higher than their 19.6 average away from home.Defensively, Houston is conceding 16.8 points per game at home, a little worse than its 16.2 average away from home.On offense, the Texans are putting up 22.0 points per game in divisional matchups, which is slightly lower than their 22.1 average outside the division.Houston has allowed 14.8 points per game in the division, which is better than its mark against the rest of the league of 17.6.The Texans are scoring 25.0 points per game in their past three games (ninth in NFL), and conceding 20.3 (ninth).Colts injury reportColts:
Daniel Jones: Full Participation in Practice (Fibula),
Sauce Gardner: Full Participation in Practice (Back),
Neville Gallimore: Full Participation in Practice (Knee),
Jaylon Carlies: Full Participation in Practice (Ankle)Texans injury reportTexans:
Denico Autry: Did Not Participate In Practice (Knee),
Trent Brown: Limited Participation in Practice (Hand),
Blake Fisher: Did Not Participate In Practice (Illness),
Jamal Hill: Did Not Participate In Practice (Hamstring),
Ajani Carter: Did Not Participate In Practice (Hamstring),
C.J. Stroud: Full Participation in Practice (Concussion),
Jalen Pitre: Limited Participation in Practice (Concussion)

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