Game Preview Houston Texans @ Indianapolis Colts
The Houston Texans travel to face the Indianapolis Colts in Week 13 of the 2025 NFL season. The game will be held at Lucas Oil Stadium in Indianapolis. Kickoff is set for Sunday, November 30, 2025, at 1:00 PM, with coverage on CBS.
The Texans enter the game with a 6-5 record, looking to improve their road performance, which stands at 2-3. Meanwhile, the Colts boast an impressive 8-3 record, including a perfect 6-0 at home. The weather forecast predicts a very cold day with light snow, but the retractable roof at Lucas Oil Stadium should keep the conditions controlled.
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Odds and Key Information
DetailInfoMatchupHouston Texans @ Indianapolis ColtsVenueLucas Oil Stadium, Indianapolis, INDateSunday, November 30, 2025Time1:00 PM ETBroadcastCBSTexans Moneyline+185Colts Moneyline-222SpreadColts -4.5 (-109), Texans +4.5 (-111)TotalOver 44.5 (-109), Under 44.5 (-112)
Houston Texans Outlook
The Texans are on a three-game winning streak, including wins over Buffalo, Tennessee, and Jacksonville. Backup quarterback Davis Mills has managed the offense efficiently with five total TD passes during that stretch.
C.J. Stroud returned to full practice this week after clearing concussion protocol and is expected to start. He has a 3-1 career record against the Colts and has built chemistry with standout wide receiver Nico Collins, who has 697 receiving yards this season.
The defense is the strength of this team, leading the NFL in total defense (264.3 yards/game) and ranking second in points allowed (16.5 per game). Edge rushers Danielle Hunter and Will Anderson Jr. have combined for 21.5 sacks.
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Chicago Bears
Philadelphia Eagles
San Francisco 49ers
Cleveland Browns
Houston Texans
Indianapolis Colts
Las Vegas Raiders
Los Angeles Chargers
Indianapolis Colts Outlook
The Colts return home after a two-game road slide and still lead the AFC South at 8-3. Quarterback Daniel Jones is expected to play despite a fibula injury. He has accounted for 22 total TDs this season.
Star running back Jonathan Taylor leads the NFL with 17 touchdowns. He’s been dominant against Houston, averaging 133.4 yards per game and scoring 10 TDs in 8 meetings. Taylor is chasing history, needing two TDs to become the fifth RB to hit 75 scrimmage TDs in under 80 games.
The offensive line will play a major role in holding off Houston’s pass rush. Expect Jones to rely on quick throws and zone reads to counter the Texans’ edge threats.
Key Matchup
Key MatchupAnalysisJonathan Taylor vs Texans Front SevenTaylor’s power running and zone reads must be effective to limit Houston’s pass rush.Texans Pass Rush vs Colts O-LineHunter and Anderson could disrupt Jones unless the Colts commit to max protection.
Betting Trends
Texans are 3-0 straight up in their last 3 games (2025).
Texans are 3-0 ATS after a loss (2025).
Colts are 8-0 SU in home games from 2024–2025.
Colts are 3-0 O/U at home in 2025.
Colts are 7-1 SU as favorites from 2024–2025.
Colts are 6-2 ATS in home games from 2024–2025.
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The Lean
The Colts are favored by 4.5 points, and their dominant home record (8-0 SU) makes them the safer pick. Our model projects a 27-21 victory for Indianapolis, making the Colts -4.5 a strong play.
The total is set at 44.5. Given both teams’ offensive potential and recent scoring trends, the over is recommended. Our projection is 48 combined points.
Pick: Colts -4.5
Total: Over 44.5
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