Patriots vs. Giants prediction, pick, odds for Monday's NFL Week 13 game

Patriots vs. Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:20 p.m.

Moneyline (ML): New England -375 (Bet $375 to win $100) | New York +300 (Bet $100 to win $300)Against the spread (ATS): New England -7.5 (-102) | New York +7.5 (-118)Over/Under (O/U): 46.5 (O: -110 | U: -110)Patriots vs. Giants betting tips preview

The New England Patriots (10-2) host a struggling New York Giants (2-10) squad on Monday, December 1, 2025 at Gillette Stadium (and best bets are available). The Giants have lost six straight games.

The Patriots bested the Cincinnati Bengals, 26-20, in their most recent outing. The Giants lost in their last game by a final score of 34-27 when they took on the Lions. Last time out for the Patriots, Drake Maye finished with 22 completions on 35 attempts (62.9%) for 294 yards, tossing one touchdown and one interception, plus five rushing attempts for 22 yards. TreVeyon Henderson carried the ball 18 times for 66 yards. Hunter Henry caught seven passes for 115 yards with one touchdown.

In the Giants’ last game, Jameis Winston threw for 366 yards on 18-36 passing (50.0%), tossing two touchdowns and one interception. Tyrone Tracy Jr. rushed for 62 yards on 20 attempts. He also hauled in three receptions for 68 yards. Wan’Dale Robinson earned 156 yards on nine receptions with one score.

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Patriots vs. Giants key injuriesPatriotsNo players are on the injury report as of 9:20 p.m. ET on Nov. 28.GiantsNo players are on the injury report as of 9:20 p.m. ET on Nov. 28.Patriots vs. Giants prediction

Patriots 30, Giants 18

Moneyline pick: Patriots -375The Patriots have an implied moneyline win probability of 78.9% in this game.New England has gone 7-1 in games they were favored on the moneyline (winning 87.5% of those games).The Patriots have played in three games as a moneyline favorite with odds of -375 or shorter and won every time.This season, New York has won two out of the 12 games, or 16.7%, in which it has been the underdog.The Giants have a record of 1-3 when they’re set as an underdog of +300 or more by oddsmakers this season.Pick ATS: Patriots (-7.5)New England’s ATS record is 7-4-1 this season.The Patriots have been favored by 7.5 points or more two times this season and have not covered the spread in any of them.In 12 games played New York has recorded six wins against the spread.The Giants are 3-0 ATS when underdogs by 7.5 points or more this year.Pick OU: Over (46.5)In four of 12 games this season, the Patriots and their opponents have combined to score more than 46.5 points.The Giants have played seven games this season that ended with a combined score over 46.5 points.These two teams average 48.5 points per game between them, 2.0 more than this game’s point total.These teams surrender 46.6 points per game combined, 0.1 more points than the over/under for this contest.

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Patriots vs. Giants prediction, pick, odds for Monday’s NFL Week 13 game

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