The AFC South features three teams with records over .500, and two of those squads face off in Week 13 on Sunday when the Houston Texans visit the Indianapolis Colts. Houston has won three in a row despite being without starting quarterback C.J. Stroud for all three of those contests, while Indianapolis is 8-3 and is aiming to rebound from an overtime loss to Kansas City last week.

Kickoff from Lucas Oil Stadium is set for 1 p.m. ET on CBS and Paramount+. The Colts are 4.5-point favorites, according to the latest Texans vs. Colts odds. The over/under for total points scored is 44.5. Before making any Texans vs. Colts picks, make sure you check out the NFL picks from the SportsLine Projection Model. Be sure to watch this game on CBS and Paramount+, where new users can get a free one-week trial. Sign up here. 

Click here to bet Texans vs. Colts at BetMGM Sportsbook, where new users get either $150 in bonus bets if your first bet wins or up to $1,500 in bonus bets if your first bet loses:

Where to bet on Texans vs. ColtsWhere to watch Texans vs. Colts on Sunday

When: Sunday, Nov. 30
Time: 1 p.m. ET
TV: CBS
Stream: Paramount+ 
Follow along: CBS Sports App

Texans vs. Colts betting preview

Odds: Colts -4.5, over/under 44.5

The Colts are 8-3 overall and 7-4 against the spread as they’ve been one of the NFL’s top stories this season. They’re also 6-5 to the Over through 11 games. The Texans’ offense has struggled, as evidenced by their 3-8 mark to the Over, but their defense has been elite, which is a big reason why Houston is 6-5 overall and 5-6 ATS.

Click here to bet Texans vs. Colts at FanDuel Sportsbook, where new users get $150 in bonus bets if their first bet of at least $5 wins:

Texans vs. Colts SGPColts -4.5 (-110, DraftKings)Over 44.5 (-108, DraftKings)Michael Pittman Jr. anytime touchdown scorer (+180, DraftKings)

Final odds: +929 at DraftKings (wager $100 to win $929)

Model’s Texans vs. Colts score prediction, picks

The model has Indy winning in more than 60% of simulations, but it sees more value backing the underdog Texans on the money line. The model has the Colts covering in half of simulations, and the Over hitting in 52% of sims. 

Texans vs. Colts score prediction: Colts 26, Texans 21

Want more Week 13 NFL picks?

You’ve seen the model’s best bets for Houston Texans vs. Indianapolis Colts. Now, get against the spread, total and money-line picks for every Week 13 NFL game here, all from the model that’s simulated every game 10,000 times.Â