Houston (6-5) brings a three-game winning streak into a matchup with Indianapolis (8-3) on Sunday, November 30, 2025 at Lucas Oil Stadium. The Colts are notable favorites in this one, with the spread sitting at 3.5 points. An over/under of 44.5 points has been set for the contest.
The Texans won versus the Buffalo Bills in their last game, 23-19.
In that matchup against the Bills, Texans QB Davis Mills completed 16 of 30 passes for 153 yards, with two touchdowns and no interceptions.
In their most recent game, the Colts lost versus the Kansas City Chiefs, 23-20.
Texans vs Colts betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 4:03 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Indianapolis (-3.5)Moneyline: Indianapolis (-178), Houston (+148)Total: 44.5 pointsTexans betting insightsHouston is 2-3 overall, with just one win against the spread, away from home.The Texans are 5-6-0 against the spread this year.The Texans have a perfect 1-0 ATS record when playing as at least 3.5-point underdogs.This season, in five away games, Houston has hit the over twice.Texans games have finished with a final combined score above the over/under three times this season.Texans leadersC.J. Stroud: 1,702 PASS YDS / 212.8 YPG / 66.5% / 11 TD / 5 INT / 29 CAR / 189 RUSH YDS / 0 TDNick Chubb: 105 CAR / 435 YDS / 39.5 YPG / 2 TD / 12 REC / 58 YDS / 5.3 YPG / 0 TDWoody Marks: 115 CAR / 422 YDS / 38.4 YPG / 2 TD / 17 REC / 185 YDS / 16.8 YPG / 2 TDNico Collins: 52 REC / 697 YDS / 69.7 YPG / 4 TDDalton Schultz: 52 REC / 497 YDS / 45.2 YPG / 1 TDJayden Higgins: 27 REC / 294 YDS / 26.7 YPG / 4 TDTexans vs Colts game infoDate: Sunday, November 30, 2025Time: 1 p.m. ETCity: Indianapolis, IndianaVenue: Lucas Oil StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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