The landscape atop the AFC is shifting dramatically with the sudden struggles of the Indianapolis Colts (8-4). Daniel Jones trying to play though a “fibula issue”. The Colts’ defense getting shredded the last few weeks. Jonathan Taylor still leads the NFL in passing but looking far more pedestrian of late. It all adds up to Indy no longer fighting for the top seed in the conference but rather battling to win the AFC South and failing that even making the playoffs.
That top spot in the AFC South is up for grabs this Sunday when Indianapolis travels to Jacksonville to take on Trevor Lawrence and the Jaguars (8-4). The loser of this game could find themselves outside the playoff picture in the AFC by the end of the weekend.
The Jaguars have won three in a row. The offense is now clicking averaging 29 points per game over that stretch and in fact, has not scored less than 25 points in a game since they returned from their bye week at the start of November. Quietly, the Jags’ defense is rolling allowing just 11 points per game during the current win streak.
Matchup to Watch: Jonathan Taylor vs. Jacksonville Run Defense
Taylor leads the NFL in rushing with 1282 yards, but the Jaguars’ defense leads the NFL in opponent rushing yards/game (82.4).
These two teams will meet again in Week 17.
Can the Colts turn their fortunes around on the road this Sunday? Lets dive into the numbers and see where they take us.
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Game Details and How to watch the Colts vs. Jaguars live SundayDate: Sunday, December 7, 2025Time: 1:00PM ESTSite: EverBank StadiumCity: Jacksonville, FLNetwork/Streaming: CBS
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Game odds for the Colts at the Jaguars
The latest odds as of Wednesday courtesy of DraftKings:
Moneyline: Indianapolis Colts (-125), Jacksonville Jaguars (+105)Spread: Colts -1.5Total: 47.5 points
This game opened at Colts -1.5 with the Game Total set at 47.5.
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Quarterback Matchup for Indianapolis at JacksonvilleColts Expected Starting QB: Daniel Jones
Last Game: 11/30 vs. Houston – 14-27, 201yds, 2TDs, 0INTs, Sacked 1 time, 1 carry for 1yd. rushing
Season: 12GP, 256-377, 3041yds, 19TDs, 7INTs, Sacked 22 times, 44 carries for 160yds rushingJaguars Starting QB: Trevor Lawrence
Last Game: 11/30 at Tennessee – 16-27, 229yds, 2TDs, 0INTs, Sacked 3 times, 3 carries for 25yds rushing
Season: 12GP, 236-395, 2636yds, 16TDs, 11INTs, Sacked 32 times, 57 carries for 235yds rushing
Colts’ injuries cause ‘house of horrors’ vs. JAX
Jay Croucher and Trysta Krick discuss upcoming Colts vs. Jaguars matchup from a betting standpoint. Croucher says Colts’ injuries cause “house of horrors” for Indy.
Colts at Jaguars team stats, betting trendsIndianapolis has lost 10 straight road games vs Jacksonville (including the 2016 London game)Jacksonville is looking to start 9-4 or better for the first time since 2017 (made AFC Championship)Indianapolis is looking to avoid becoming the 6th team since the 1970 Merger to miss the playoffs after starting 7-1 or better through 8 games (2012 Bears, 1996
Washington, 1988 Saints, 1987 Chargers, 1975 Dolphins)Daniel Jones is 3-3 with 9 total TD to 9 turnovers and 15 sacks away from Indianapolis this season (including Week 10 game vs. Atlanta in Germany) compared to 5-1 at home with 15 total TD to 1 turnover and 7 sacks takenThe Jaguars have won 4 of their last 5 home games against AFC South teamsThe Jaguars have covered the Spread in 4 of their last 5 matchups against AFC South opponentsThe Jaguars’ last 5 games versus the Colts have gone over the TotalColts Player InjuriesCB Sauce Gardner (calf) is listed as doubtful for Sunday’s game CB Kenny Moore II (illness) is listed as questionable for Sunday’s gameWR Josh Downs (hip) is listed as questionable for Sunday’s gameDE Tyquan Lewis (ankle) is listed as questionable for Sunday’s gameLB Jaylon Carlies (ankle) has been ruled OUT of Sunday’s game
Jaguars Player InjuriesWR Parker Washington (hip) is listed as questionable for Sunday’s gameLT Walker Little (concussion) is listed as questionable for Sunday’s gameRG Patrick Mekari (undisclosed) is listed as questionable for Sunday’s gameDT Arik Armstead (hand) is listed as questionable for Sunday’s gameDE Travon Walker (knee) is listed as questionable for Sunday’s gameLB Foyesade Oluokun hamstring) is listed as questionable for Sunday’s gameLB Devin Lloyd (chest) is listed as questionable for Sunday’s gameFS Andrew Wingard (concussion) is listed as questionable for Sunday’s gameDE Danny Striggow (undisclosed) is listed as questionable for Sunday’s gameP Logan Cooke (shoulder) is listed as questionable for Sunday’s gameLS Ross Matiscik (undisclosed) is listed as questionable for Sunday’s gameG Chuma Edoga (undisclosed) is listed as questionable for Sunday’s gameRotoworld Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Colts and the JaguarsMoneyline: Rotoworld Bet is staying away from a play on the Moneyline.Spread: Rotoworld Bet is leaning towards a play ATS on the Jacksonville Jaguars at +1.5.Total: Rotoworld Bet is recommending a play on the UNDER on the Game Total of 47.5.
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