The Arizona Cardinals (3-9) are an underdog by 8.5 points as they try to halt a four-game skid in a matchup with the Los Angeles Rams (9-3) on Sunday, December 7, 2025 at State Farm Stadium.

Rams vs. Cardinals game infoGame day: Sunday, December 7, 2025Game time: 4:25 p.m. ETTV channel: FOXLocation: Glendale, ArizonaStadium: State Farm StadiumLive stream: Watch this game on Fubo (Regional restrictions may apply)

Watch Los Angeles Rams vs. Arizona Cardinals on Fubo! (Regional restrictions may apply)

Rams vs. Cardinals odds & betting linesSpread favorite: Los Angeles (-8.5)Moneyline: Los Angeles (-439), Arizona (+336)Total: 47.5 points

NFL odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 10:55 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Rams vs. Cardinals recent matchupsLos Angeles has gone 3-2 versus Arizona over the last five matchups between the two teams.The Cardinals are 3-2 against the spread in those games against the Rams, while the two teams have gone over the point total on three occasions.Los Angeles scored 103 points in those five matchups, with Arizona putting up 100.Rams vs. Cardinals betting insightsLos Angeles has eight wins against the spread through 12 opportunities this season (8-4-0). The Rams have been the moneyline favorite 11 times this season, and they have gone 9-2 in those games. Arizona has six wins against the spread so far this season (6-6-0). This is the 10th game this year the Cardinals are the moneyline underdog. They are 1-8 in games as the underdog.Rams scoring insightsThe Rams are averaging fewer points at home (25.5) than away (30.2).On defense, Los Angeles allows fewer points at home (15.2 per game) than on the road (19.8).The Rams are scoring 28.7 points per game in divisional contests, which is better than their 27.6 average versus the rest of the league.Los Angeles is conceding 23.7 points per game in divisional contests, which is higher than its 15.4 average in non-division games.The Rams rank sixth in scoring offense (27.7 points per game) and 10th in scoring defense (19.0 points per game surrendered) over their last three contests.Cardinals scoring insightsAt home, the Cardinals score 22.8 points per game, higher than their 21.3 average away from home.On defense, Arizona concedes more points at home (27.0 per game) than on the road (23.5).On offense, the Cardinals average fewer points in division games (19.8) than against the rest of the league (23.3).Arizona is conceding 31.0 points per game in divisional matchups, which is higher than its 22.4 average in non-division games.In their past three games, the Cardinals are putting up 21.0 points per game (18th in league) and giving up 29.3 per game (fourth-worst).Rams injury reportRams:
Tutu Atwell: Full Participation in Practice (Hamstring),
Byron Young: Limited Participation in Practice (Knee),
Kyren Williams: Limited Participation in Practice (Ankle),
Omar Speights: Limited Participation in Practice (Ankle),
Kamren Kinchens: Limited Participation in Practice (Shoulder),
Darious Williams: Did Not Participate In Practice (Tibia),
Poona Ford: Did Not Participate In Practice (Calf),
Davante Adams: Did Not Participate In Practice (Hamstring)Cardinals injury reportCardinals:
L.J. Collier: Limited Participation in Practice (Knee),
Dadrion Taylor-Demerson: Did Not Participate In Practice (Ankle),
Walter Nolen: Did Not Participate In Practice (Knee),
Josh Sweat: Did Not Participate In Practice (Rest),
Max Melton: Did Not Participate In Practice (Heel),
Marvin Harrison Jr.: Did Not Participate In Practice (Heel),
Greg Dortch: Did Not Participate In Practice (Chest),
Trey Benson: Did Not Participate In Practice (Knee),
Xavier Weaver: Limited Participation in Practice (Hamstring),
Kelvin Beachum: Limited Participation in Practice (Groin),
Christian Jones: Limited Participation in Practice (Knee),
Emari Demercado: Limited Participation in Practice (Ankle)

Watch Los Angeles Rams vs. Arizona Cardinals on Fubo! (Regional restrictions may apply)