The Arizona Cardinals (3-9) take a four-game losing streak into their contest with the Arizona Cardinals on Sunday, December 7, 2025 at State Farm Stadium. The Rams are notable favorites in this one, with the spread sitting at 9.5 points. The over/under is set at 47.5 in the contest.
The Cardinals lost to the Tampa Bay Buccaneers, 20-17, in their last game.
Cards QB Jacoby Brissett was 29-for-40 for 301 yards, with two TDs and one INT, versus the Buccaneers.
In their most recent game, the Rams lost versus the Carolina Panthers, 31-28.
Cardinals vs Rams betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:59 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: Los Angeles (-9.5)Moneyline: Los Angeles (-529), Arizona (+394)Total: 47.5 pointsCardinals betting insightsArizona has covered the spread once at home, and is 1-5 overall there this year.The Cardinals have covered the spread in a game six times this season (6-6-0).In games they have played as 9.5-point underdogs or more, the Cardinals have a perfect ATS record of 1-0.This season, in six home games, Arizona has hit the over five times.This year, seven Cardinals games have gone over the point total.Cardinals leadersBrissett: 2,188 PASS YDS / 243.1 YPG / 67.5% / 13 TD / 4 INT / 27 CAR / 116 RUSH YDS / 1 TDBam Knight: 74 CAR / 255 YDS / 25.5 YPG / 4 TD / 19 REC / 142 YDS / 14.2 YPG / 1 TDEmari Demercado: 31 CAR / 241 YDS / 30.1 YPG / 0 TD / 8 REC / 64 YDS / 8.0 YPG / 1 TDTrey McBride: 88 REC / 879 YDS / 73.3 YPG / 8 TDMarvin Harrison Jr.: 40 REC / 594 YDS / 59.4 YPG / 4 TDMichael Wilson: 50 REC / 570 YDS / 47.5 YPG / 1 TDCardinals vs Rams game infoDate: Sunday, December 7, 2025Time: 4:25 p.m. ETCity: Glendale, ArizonaVenue: State Farm StadiumTV channel: FOXLive stream: Watch on Fubo (Regional restrictions may apply)
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