The Buffalo Bills are set for a high-stakes AFC showdown against the Cincinnati Bengals on Sunday afternoon, with kickoff scheduled for 1:00 p.m. ET.

Throughout the week, uncertainty around the status of tight end Dalton Kincaid dominated discussions regarding the Bills’ offensive outlook. Kincaid, who has missed the past three games with a hamstring injury and dealt with an additional knee issue this week, managed a trio of limited practices leading up to the contest.

While the third-year tight end remains officially listed as questionable, ESPN’s Adam Schefter reports Kincaid plans to try to play, with his final status expected to be determined only after his pregame routine. This potential return is particularly crucial given the Bills are facing a Cincinnati defense that has proven highly vulnerable to opposing tight ends this season.

This update prompted Dimers’ analysts to reevaluate their Bills vs. Bengals predictions and player stat projections using new simulations that factored in Kincaid’s potential, albeit compromised, availability against the Bengals’ favorable matchup.

The results of Dimers’ simulations were compared to updated sportsbook odds to compile the data-driven Bills-Bengals preview below.

Bengals vs. Bills betting preview

Utilize the interactive widget below to see the latest spread, over/under, and moneyline betting odds and probabilities for the Bengals-Bills game at Highmark Stadium.

This prediction and best bet for Sunday’s NFL matchup between the Bengals and Bills is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Bengals vs. Bills matchup, including where the game is and what time it kicks off.

Teams: Cincinnati Bengals vs. Buffalo BillsDate: Sunday, December 7, 2025Kickoff: 1 p.m. ESTLocation: Highmark StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL clash between the Bengals and Bills.

Spread: Bengals +5.5 (-102), Bills -5.5 (-120)Moneyline: Bengals +230, Bills -275Total: Over/Under 53.5 (-108/-112)

The odds and lines presented here are the best available from selected sports betting sites at the time of publication and are subject to change.

Expert prediction: Bengals vs. Bills

Leveraging cutting-edge data analysis and computer power, the experts at Dimers have executed 10,000 simulations of Sunday’s Bengals vs. Bills matchup.

According to Dimers’ renowned predictive analytics model, the Bills are more likely to defeat the Bengals at Highmark Stadium. This prediction is based on the model giving the Bills a 66% chance of winning the game.

Furthermore, Dimers predicts that the Bengals (+5.5) have a 54% chance of covering the spread, while the 53.5-point over/under has a 52% chance of staying under.

These predictions and probabilities are correct at the time of publication but are subject to change.

Bengals vs. Bills best bet

Our top pick for the Bengals vs. Bills Week 14 NFL game is to bet on the Bengals moneyline (+230).

This betting advice is formulated through comprehensive modeling and valuable wagering intelligence, designed to assist you in making more informed investments.

While the Bills are more likely to win the game, according to Dimers, betting on the Bengals moneyline is the best option due to the 4.1% edge identified when comparing Dimers’ data-driven probabilities to the betting odds.

Score prediction for Bengals vs. Bills

Dimers’ predicted final score for the Cincinnati vs. Buffalo game on Sunday has the Bills winning 28-23.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL props are a great way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Bengals and Bills, along with projected player stats.

Cincinnati BengalsFirst touchdown scorer predictionsJa’Marr Chase: 9.4% probabilityChase Brown: 7.9% probabilityTee Higgins: 7.1% probabilityAnytime touchdown predictionsJa’Marr Chase: 47.5% probabilityChase Brown: 41.8% probabilityTee Higgins: 38.6% probabilityProjected box score leadersQB passing yards: Joe Burrow, 256 yardsReceiving yards: Ja’Marr Chase, 88 yardsRushing yards: Chase Brown, 57 yardsBuffalo BillsFirst touchdown scorer predictionsJames Cook: 11.6% probabilityJosh Allen: 10.4% probabilityKhalil Shakir: 4.7% probabilityAnytime touchdown predictionsJames Cook: 56.5% probabilityJosh Allen: 52.5% probabilityKhalil Shakir: 28.7% probabilityProjected box score leadersQB passing yards: Josh Allen, 237 yardsReceiving yards: Khalil Shakir, 50 yardsRushing yards: James Cook, 103 yardsNFL Week 14: Bengals vs. Bills

Get ready for Sunday’s matchup between the Bengals and Bills in Week 14 of the National Football League season at Highmark Stadium, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions in this preview are derived from 10,000 data-driven simulations of the Bengals vs. Bills matchup, and they are correct at the time of publishing. They aim to help you make better decisions when placing bets at online sportsbooks.

If you or a loved one has questions or needs to talk to a professional about gambling, call 1-800-GAMBLER or visit 1800gambler.net for more information.

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