The Eagles are 1.5-point road favorites over the Chargers on Monday Night Football
Justin Herbert (broken hand) is expected play despite having surgery this week
See the Eagles vs Chargers odds, picks and predictions for Monday Night Football, below
Everyone wants to write off the defending champion Eagles (8-4, 4-2 away) and I get it. The offense has looked horrendous all season, and the loss to the Bears on Black Friday was tough to watch.
However, a trip across the country to face the depleted Chargers (8-4, 5-2 home) is just what the doctor ordered. Online sportsbooks appear to feel the same way, pegging Philly as road favorites in the latest MNF odds.
Kickoff is scheduled for 8:15pm ET/5:15pm PT from SoFi Stadium, in Inglewood, CA, with ESPN providing the broadcast coverage. Below, you’ll find the latest Eagles vs Chargers odds, plus my picks and predictions for Monday Night Football.
Eagles vs Chargers Odds
Before making any Monday Night Football wager, be sure to consult the best football betting apps. Philadelphia is a 1.5-point favorite over at FanDuel, compared to -2.5 at DK.
DraftKings is the spot to bet the under, as they’re offering a 42.5 point total, while most other commercial books are a point lower.
Per the NFL public betting percentages, Philly has been money against the spread when the line sits between -3 and +3 in the Nick Sirianni era. The Eagles are 13-2 ATS in those instances, and 19-6 if you include the playoffs.
Odds as of Dec. 7. New customers can claim the DraftKings promo code and get a bonus to bet on MNF.
Eagles vs Chargers Picks and Predictions
ATS Pick: Eagles -1.5 (-115) at FanDuel
Speaking of playoffs, Monday Night Football will go along way to determining both of these teams postseason fate.
The Eagles currently have a 90% chance of winning the NFC East, and a win would bump that up to 95%. LA on the other hand can jump to a 74% chance of making the playoffs with a victory, but will fall to just 50% for a loss.
My handicap for this game is pretty simple. Philadelphia is far too talented to own such an underwhelming record, while the Chargers are way too beat up on offense to give themselves a chance.
Let’s start with the LA side of things. Justin Herbert suffered a broken left hand last week, but still intends to play on MNF. He underwent successful surgery earlier in the week, and will reportedly suit up in a cast.
Herbert has been under siege ever since star tackle Joe Alt went down, and is operating behind an offensive line that is without multiple starters. Herbert has been pressured on 41% of his drop backs this season, and has taken 10 sacks in his last three games since Alt was put on IR.
Justin Herbert Pressure Stats
It was only a matter of if, not when, he was going to be injured, and I honestly don’t expect him to make it through the regular season.
The Chargers are a completely different team with and without Alt in the lineup, ranking top-five in success rate when he suits up, and bottom-five when he doesn’t. They’re averaging only 20 points per game since he went to IR, while LA has put up fewer than 11 points in two of the seven games he’s missed.
The hit on Justin Herbert that sent him to the locker room with a left hand injury. He is questionable to return. Still in the locker room. pic.twitter.com/KXxG3anZXl
— James Palmer (@JamesPalmerTV) November 30, 2025
LA is expecting rookie RB Omarion Hampton to return on Monday, and they would be wise to lean run heavy in this matchup. Eagles star defensive tackle Jalen Carter is out, while Philly ranks 19th in EPA per rush, compared to 9th in EPA per pass and eighth in pass rush win rate.
As for the Eagles offense, it’s been what’s holding them back in the Super Bowl 60 odds. Philly ranks 22nd in success rate and 14th in EPA per play, while Saquon Barkley has looked nothing like the 2,000 yard rusher he was last season.
With Barkley and the run game stuck in the mud, the Eagles should try to lean pass heavy in this matchup. The A.J. Brown – DeVonta Smith combo is one of the best pass catching duo’s in football, and LA has a very vulnerable piece in the secondary they can pick on.
Especially with the Bears’ defensive injuries, AJ Brown and DeVonta Smith can be a nightmare. Just last week:
AJ Brown: 8 REC, 110 YDS, 1 TD
DeVonta Smith: 6 REC, 89 YDS
Don’t let the Eagles’ recent struggles fool you. These dudes can straight up BALL.
Video: @NFLPerformances pic.twitter.com/WHzuPICqhE
— Bears Facts (@DaBearsTakeOver) November 25, 2025
Cornerback Cam Hart has allowed a 20% target rate this season, which is the second highest in football. He’s PFF’s 112th graded corner, and is allowing 14 yards per reception.
The Eagles are at their best when they are stretching the field with vertical passes, and then taking advantage of light boxes when the defense over corrects. I expect them to push the ball tonight, and at least somewhat resemble a team that was unstoppable during last year’s postseason.
Ultimately, I have faith Philadelphia will have sorted out its issues after an extended rest, and I have zero trust the Chargers can keep Herbert safe and upright. Fly Eagles Fly on the road as short favorites.