The Buffalo Bills are set to visit the division-rival New England Patriots at Gillette Stadium on Sunday for a critical Week 15 AFC East matchup, with playoff hopes hanging in the balance.

Throughout the week, discussions leading up to the game have been dominated by uncertainty surrounding the availability of the Bills’ top pass rusher, Joey Bosa. Bosa, who missed the Week 14 win against the Cincinnati Bengals due to a hamstring injury—his first game missed this season—could be poised for a quick return.

Head Coach Sean McDermott provided an encouraging update on Monday, stating he believes there is a chance the 30-year-old defensive end could play against New England. While the coach cautioned that the medical team will take it “one day at a time,” his optimism points toward a potential return that would be crucial against a division opponent.

“I believe there is,” said McDermott when asked about Bosa’s chance of suiting up, indicating the team will await a definitive status update later in the week.

This crucial health update prompted analysts to reevaluate their Bills vs. Patriots predictions and defensive stat projections using new simulations that factored in Bosa’s potential, game-changing return against a struggling Patriots offense.

The results of these simulations were compared to updated sportsbook odds to compile the data-driven Bills-Patriots preview below.

Bills vs. Patriots betting preview

Explore the interactive widget below to see the latest spread, total, and moneyline betting odds and probabilities for the Bills-Patriots matchup at Gillette Stadium.

This prediction and best bet for Sunday’s NFL matchup between the Bills and Patriots is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Bills vs. Patriots matchup, including where the game is and what time it kicks off.

Teams: Buffalo Bills vs. New England PatriotsDate: Sunday, December 14, 2025Kickoff: 1 p.m. ESTLocation: Gillette StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL matchup between the Bills and Patriots.

Spread: Bills -4.5 (-110), Patriots +4.5 (-110)Moneyline: Bills -102, Patriots +165Total: Over/Under 48.5 (-110/-110)

The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Bills vs. Patriots

Using trusted data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Sunday’s Bills vs. Patriots game.

According to Dimers’ highly acclaimed predictive analytics model, the Bills are more likely to defeat the Patriots at Gillette Stadium. This prediction is based on the model giving the Bills a 56% chance of winning the game.

Furthermore, Dimers predicts that the Patriots (+4.5) have a 62% chance of covering the spread, while the over/under total of 48.5 points has a 55% chance of staying under.

As always, these predictions and probabilities are correct at the time of publication but are subject to change.

Bills vs. Patriots best bet

Our top pick for the Bills vs. Patriots Week 15 NFL game is to bet on the Patriots +4.5 (-110).

This betting advice is formulated through detailed modeling and valuable betting intelligence, designed to assist you in making more informed decisions.

Score prediction for Bills vs. Patriots

Dimers’ predicted final score for the Buffalo vs. New England game on Sunday has the Bills winning 24-22.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL Week 15: Bills vs. Patriots

Get ready for Sunday’s game between the Bills and Patriots in Week 15 of the NFL season at Gillette Stadium, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions in this article are based on 10,000 data-driven simulations of the Bills vs. Patriots game, and they are correct at the time of publication to help you make more informed choices when placing bets at online sportsbooks.

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