The New England Patriots and Buffalo Bills will meet for the second time in 2025. The Patriots beat Buffalo, 23-20, in the first meeting on Oct. 5 in a Sunday Night Football game at Highmark Stadium. This week, the Patriots will look for their third straight win over Buffalo and look to complete their 28th series sweep and first since the 2019 season.

The teams have split the annual series in each of the last two years. Last season, the Patriots lost at Buffalo, 24-21, on Dec. 22 and then two weeks later beat Buffalo in the season-finale, 23-16, on Jan. 5, 2025.

This week’s game will be the 133rd meeting between the two teams. New England holds a 80-51-1 edge in the series and has won 39 of the last 50 regular season games between the clubs, dating back to 2000.

The Patriots are 41-24 all-time at home against Buffalo, including 18-5 at Gillette Stadium.

The series between the AFC East rivals began in 1960. The Patriots’ 80 wins over the Bills are their highest victory total over any opponent, four higher than their next highest win total against the New York Jets (76).

After seven-straight series sweeps and 15-consecutive Patriots wins from 2003-10, Buffalo ended the streak with a 34-31 victory at Ralph Wilson Stadium in the first meeting between the teams in 2011. The 15-game win streak is tied for the longest streak over a single opponent in team history with 15-straight wins over the New York Jets.

The teams have had many memorable matchups over the years, including a span from 1999 to 2001, where four-of-six contests were decided in overtime.