The Kansas City Chiefs’ playoff hopes took a big hit this past weekend when the Chiefs fell to the Texans and the Chargers beat the Eagles in overtime. Now, the Chiefs need a lot to go their way if they want to return to the postseason, including beating the Chargers in Week 15.

The Chargers beat the Chiefs in Brazil back in Week 1 and now have a chance to mathematically eliminate their division rival. Can they pull off another upset? Let’s find out what the oddsmakers think.

Odds via Caesars Sportsbook

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Chargers Injury ReportChiefs Injury Report

To say this has been a down year for Patrick Mahomes would put it lightly. Not only is he on the verge of missing the playoffs, but he’s been the worst quarterback to bet on over the past two years. He can’t afford any mistakes in the final stretch of the season if he wants any hope of keeping his playoff streak alive. He has completed just 63.1% of passes in 2025.

In this week’s edition of the Road to 272 Bets, I wrote about why I’m taking the points with the Chargers:

I’m surprised to see the Chiefs are 4.5-point favorites in this spot. Not only have they already lost to the Chargers this season, and they have a losing record, but they have only five wins all season that have come by 5+ points. The betting market continues to evaluate the Chiefs as if they’re the Chiefs of cold, but they’re now on a four-game losing streak and have proven they are a different football team in 2025.

I wouldn’t be shocked to see if the Chiefs win, but there’s no way I can back this team to win by margin when facing a team that’s currently in the playoff picture.

Pick: Chargers +4.5 (-110) via Caesars

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Odds refresh periodically and are subject to change.

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You can check out all of Iain’s bets here!