The Cardinals face seven former No. 1 picks and four Heisman winners.

The Arizona Cardinals released their 2025 regular-season schedule and we know when they face their 17 opponents. They open the season on the road against the New Orleans Saints and close the season on the road against the Los Angeles Rams.

They have a fairly light start to the season but have a very challenging final six games.

They also face a good number of players who were selected first overall in the draft and who were Heisman Trophy winners in college.

In all, the Cardinals will face seven former No. 1 picks and four Heisman winners.

Former No. 1 draft pick on the Cardinals’ 2025 schedule

The Cardinals have their own former No. 1 overall pick in quarterback Kyler Murray. These are the former No. 1 picks they will face this season.

Panthers QB Bryce Young (Week 2)Titans QB Cam Ward (Week 5)Jaguars QB Trevor Lawrence (Week 12)Jaguars DE Travon Walker (Week 12)Buccaneers QB Baker Mayfield (Week 13Rams QB Matthew Stafford (Weeks 14, 18)Bengals QB Joe Burrow (Week 17)Heisman Trophy winners on Cardinals’ schedule

The Cardinals also have a former Heisman winner, as Murray was that guy at Oklahoma.

Jaguars WR/CB Travis Hunter (Week 12Buccaneers QB Baker Mayfield (Week 13)Rams QB Matthew Stafford (Weeks 14, 18)Bengals QB Joe Burrow (Week 17)2025 Arizona Cardinals scheduleWeek 1: (Away) New Orleans Saints, Sunday, Sept. 7, 1 p.m. ET (10 am. AZ time)Week 2: (Home) Carolina Panthers, Sunday, Sept. 14, 4:05 p.m. ET (1:05 p.m. AZ time)Week 3: (Away) San Francisco 49ers, Sunday, Sept. 21, 4:25 p.m. ET (1:25 p.m. AZ time)Week 4: (Home) Seattle Seahawks, Thursday, Sept. 25, 8:15 p.m. ET (5:15 p.m. AZ time)Week 5: (Home) Tennessee Titans, Sunday, Oct. 5, 4:05 p.m. ET (1:05 p.m. AZ time(Week 6: (Away) Indianapolis Colts, Sunday, Oct. 12, 1 p.m. ET (10 a.m. AZ time)Week 7: (Home) Green Bay Packers, Sunday, Oct. 19, 4:25 p.m. ET (1:25 p.m. AZ time)Week 8: BYE WEEKWeek 9: (Away) Dallas Cowboys, Monday, Nov. 3, 8:15 p.m. ET (6:15 p.m. AZ time)Week 10: (Away) Seattle Seahawks, Sunday, Nov. 9, 4:05 p.m. ET (2:05 p.m. AZ time)Week 11: (Home) San Francisco 49ers, Sunday, Nov. 16, 4:05 p.m. ET (2:05 p.m. AZ time)Week 12: (Home) Jacksonville Jaguars, Sunday, Nov. 23, 4:05 p.m. ET (2:05 p.m. AZ time)Week 13: (Away) Tampa Bay Buccaneers, Sunday, Nov. 30, 1 p.m. ET (11 a.m. AZ time)Week 14: (Home) Los Angeles Rams, Sunday, Dec. 7, 4:25 p.m. ET (2:25 p.m. AZ time)Week 15: (Away) Houston Texans, Sunday, Dec. 14, 1 p.m. ET (11 a.m. AZ time(Week 16: (Home) Atlanta Falcons, Sunday, Dec. 21, 4:05 p.m. ET (2:05 p.m. AZ time)Week 17: (Away) Cincinnati Bengals, Saturday, Dec. 27/Sunday, Dec. 28, TBDWeek 18: (Away) Los Angeles Rams, Date, time TBD

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