The Buffalo Bills have known their opponents for the 2025 season for months.

Now, they know when they will face their foes next season.

The NFL officially released its full slate of games for the 2025 season on Wednesday.

The schedule is full of intrigue as the Bills look to build toward their sixth-consecutive AFC East crown. However, Buffalo will face off against multiple teams that have ended their season in recent years.

With that, here are six takeaways from the Bills’ 2025 NFL schedule:

It’s an MVP start to the season

Buffalo will host the Baltimore Ravens in Week 1 on “Sunday Night Football” as the NFL’s marquee game to open the season.

The previous two NFL MVPs face off in prime time. Both the Ravens’ Lamar Jackson and Bills’ Josh Allen have been electrifying over the past few seasons, easily being the most important pieces to their respective teams’ success. The NFL made certain to get them on display from the get-go.

Early-season home cooking

Buffalo will play four of their first five games at home. The most difficult challenge occurs in Week 1, when the Bills host Baltimore. Buffalo then hosts four teams that are rebuilding their rosters. Buffalo will host Miami, New Orleans, and New England in Weeks three through five.

There is a strong possibility that the Bills close this portion of their schedule undefeated.

The most challenging games

Buffalo will face stout competition throughout the season. We know about the Ravens already. The Bills will face both Super Bowl 59 combatants, the Kansas City Chiefs and Philadelphia Eagles, throughout the year. Buffalo also faces the surging Cincinnati Bengals and MVP candidate Joe Burrow.

The good news? These challenging games are spread out. After Baltimore in Week 1, the Bills will face Kansas City in Week 9, Cincinnati in Week 14, and Philadelphia in Week 17.

Even better news? Buffalo will face all of these teams at Highmark Stadium. The final slate of games at the field, still referenced as Rich Stadium by many, will see some of the strongest teams come to One Bills Drive.

Favorable travel schedule

Buffalo will play one game out of the Eastern Time Zone. Buffalo travels to Houston in Week 12 for a Thursday night matchup.

While the Bills will have to adjust to some different start times, they will not spend a great deal of time in the air. They travel the second-fewest miles among teams this season, per ESPN.

The end of the era

Buffalo will play their final game at Highmark Stadium against the New York Jets in Week 18. If the Bills are in the spot that they’ve been in over the past few seasons, Week 18 might not mean much in the standings. The Bills have sewn up their postseason aspiration well in advance of the final regular season game.

However, this game will be marked by memories of reflections as the Bills prepare to move into their new home, just across the street from the historical stadium.

It’s fitting that Buffalo faces off against the Jets for their final regular-season game at the old Highmark Stadium. Buffalo faced the Jets in the first home game at the stadium on September 30, 1973. Buffalo won an electric defensive affair, 9-7.

Overall reaction

Bills fans have to be smiling with this schedule. From a fan perspective, four early-season games at home in nice weather will lead to a slew of broken tables in Orchard Park.

Buffalo will avoid a massive grind, as the Bills will have time to plan for some of the most challenging teams. Their lack of travel and convenience of playing several tough teams at home make this quite a prelude for a historic season.